Synthesis and Physicochemical Characterization of New Amidic Derivative of Sodium Alginate
Subject Areas :
Shokouh
Khodayar
1
(Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.)
Mohammad Reza
Shushizadeh
2
(Marine Pharmaceutical Science Research Center and Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Iran.)
Elham
Tahanpesar
3
(Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran)
Behzad
Sharif Makhmalzadeh
4
(Nanotechnology research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran)
Haleh
Sanaeishoar
5
(Department of chemistry, Ahvaz branch, Islamic Azad university)
Keywords: Ethylenediamine, Amidation reaction, Sodium alginate, Biohydrogel,
Abstract :
In this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase reaction using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) and N-hydroxy succinimide (NHS) as coupling reagents to synthesis ethylenediamine-grafted amphiphilic sodium alginate-amide derivative (NaA-g-EDA). Synthesized derivative showed no environmental sensitivity but the swelling percentage of hydrogels shows that hydrogels obtained from NaA-g-EDA had higher water absorption compared to non-functionalized sodium alginate. It seems that hydrogels can uptake water more than 100% of their weight but in a slow manner. This character is a perfect property for wound dressing. Biodegradable synthesized hydrogel can be decomposed into non-toxic by-products. The purity and grafting of copolymers were characterized using fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR), X-ray diffraction (XRD), and elemental analysis (CHNX). These analytical methods confirmed the structure of NaA-g-EDA.