Study of adsorption and release of 5-fluorouracil on Graphene oxide as anticancer drug delivery system
Subject Areas : International Journal of Bio-Inorganic Hybrid Nanomaterials
Keywords: in vitro, MTT Assay, Adsorption, Graphene oxide, anticancer, 5-Fluorouracil, Drug delivery, Release,
Abstract :
One of the most common treatments for cancer is chemotherapy. The most important disadvantage of most drugs used in chemotherapy is the inability to effectively penetrate the tumor tissue, not reaching the effective concentration, and their unwanted side effects on healthy tissues. In recent years, Graphene Oxide has been utilized in various pharmaceutical applications since of its capacity to target particular sites. Within the present work, a modern type of Graphene Oxide was arranged and loaded with 5-fluorouracil for controlled drug conveyance applications. A novel drug conveyance framework was arranged from 5-fluorouracil and Graphene oxide [GO-5-FU], containing Graphene oxide (GO) and 5-fluorouracil (5-FU) anticancer drug for controlled release of drug. This system was synthesized by connecting GO to 5-FU through solid π–π stacking interaction. The 5-FU discharge and stacking were emphatically pH-dependent and suggest an H-bonding interaction between GO and 5-FU. The resultant GO-5-FU was characterized by Fourier transforms infrared spectroscopy (FTIR), X-ray diffraction (XRD) analysis, and, filtering electron microscopy (SEM). Other than that, swelling and in vitro drug discharge considers were also carried out at pH 1.2, 5, 7.4 and 10 at 37°C. Furthermore, the equilibrium adsorption data were analyzed by Freundlich and Langmuir models. The anticancer action of the GO-5-FU was surveyed utilizing an MTT test against MCF-7 and HepG2 cells. The come about findings that the created GO-5-FU are likely to be viable drug carriers for medicate conveyance applications.