The effect of MgO@FO nanoparticles on liver enzymes in male mice injected with Thioacetamide
Subject Areas : International Journal of Bio-Inorganic Hybrid Nanomaterials
Keywords: Evaluation, nanoparticles, enzymes, Hydroethanolic extract, Magnesium oxide,
Abstract :
Magnesium oxide nanoparticles are characterized with a wide variety of applications and are massproduced throughout the world. However, questions remain regarding their safety. In this study, the hepatoprotective effects of fig and olive hydroethanolic extract in Quranic ratios of 1: 7 in the prevention of thioacetamide-induced liver damage in male Syrian mice were investigated. In addition, hematology, biochemistry, and histopathology of the rats are examined at various concentrations (75,150,300 mg / kg) over 28-days period. In this experimental study, 36 male rats were divided into 6 groups of 6. Control without any drug treatment, the control group treated with thioacetamide 100 mg / kg, the third group treated with 300 mg / kg metformin, and groups 4, 5 and 6 with coated concentrations of 75,150,300 mg / kg, were gavaged every other day for 28 days. At the end of the experiment and the mean activity of ALT, AST and ALP enzymes was compared with the control group. The results of one-way analysis of variance (ANOVA) showed a significant increase in serum SGOT level in thioacetamide + metformin and thiostamide groups compared to other groups (P <0.001). Thioacetamide + metformin and thioacetamide were seen compared to other groups (P <0.001). A significant increase in ALP enzyme activity was observed in all groups compared to the control group receiving 150mg / kg coated nanoparticles (P <0.01). The combination of hydroathanolic extract of fig and olive fruit with Quranic ratios may modulate liver enzymes.