The effect of MgO@FO nanoparticles on liver tissue in male mice injected with thioacetamide
Subject Areas : International Journal of Bio-Inorganic Hybrid Nanomaterials
Keywords: nanoparticles, Mice, liver tissue, MgO, Thioacetamide,
Abstract :
Background and Aim: There are many promising advances in biological detection and the use of nanostructures and multifunction devices. The Qur'an also mentions foods that undoubtedly paying attention to them and applying the instructions given about them can ensure physical and mental health. In this study, the protective effects of liver hydroathanolic extract of fig and olive in Quranic ratios of 1: 7 in the prevention of thioacetamide-induced liver damage in male mice were investigated. Materials and Methods: In this study, doses of 75, 150 and 300 mg/kg MgO@FO were injected into one-month-old male mice. Chemical precipitation method was used to synthesize MgO (2 to 3 nm) and MgO@FO quantum dots. Their physical properties were evaluated by X-ray diffraction (XRD), visible ultraviolet (UV) spectroscopy and transmission electron microscopy (TEM). Results: Histological studies of liver tissue in the group treated with plant extracts and nanoparticles. The nanoparticles coated with hydroethanolic extract of fig and olive oil had the least damage and bleeding compared to the group receiving thioacetamide at a concentration of 100 kg/mg. It was shown that the obtained MgO@FO quantum dots have a high hexagonal crystal structure. Conclusion: The combination of hydroethanolic extract of fig and olive fruit with Quranic ratios may protect the liver tissue probably by increasing the activity of antioxidant compounds in the above extract and thus reducing oxidative stress and lipid peroxidation caused by thivastamide.