New rodenticides design based on experimental results of real rodenticides’s structural study
Subject Areas : International Journal of Bio-Inorganic Hybrid Nanomaterials
Keywords: IC50, Hydrophobicity, Acetylcholinesterase inhibition, logP, Organophosphorus rodenticides,
Abstract :
Organophosphorus rodenticides are used non-systemically and with contact, digestive and penetrating effects to control a wide range of rodent and sucking pests in the agricultural industry, and by inhibiting the acetylcholinesterase enzyme, they disrupt the rodent's nervous system and destroy them. The findings of the experimental studies of this research (including the hydrophobicity parameter of some organic phosphorus compounds and the level of inhibition of the corresponding enzyme by these compounds as inhibitors) show that the toxicity of the compound decreases in exchange for an increase in hydrophobicity. Therefore, the design of hydrophilic organic phosphorus compounds produces a more lethal product, and on the contrary, a less effective product is obtained with hydrophobic alternatives. For a group of chemical compounds with specific biological properties, reliable equations can be obtained by using quantitative structure-activity relationships, which are effective in the design of new substances with the desired level of effectiveness.