Evaluation of antibacterial properties of chitosan nanoparticles against Esherichi coli isolated from diabetic ulcers
Subject Areas : International Journal of Bio-Inorganic Hybrid Nanomaterials
Keywords: antibacterial effect, Escherichia coli, nanotechnology, Chitosan Nanoparticles, Diabetic ulcers,
Abstract :
Nanotechnology is the science to create products with enormous potential to treatdiseases. Diabetic ulcers and their infections have affected many people around the world, and manypeople die each year from infections caused by microorganisms in these ulcers. The aim of this studywas to investigate the antibacterial properties of chitosan nanoparticles against Escherichia coli isolatedfrom diabetic wounds. Morphological evaluation and substructure of nanoparticles synthesized byion gelling method were performed by XRD and TEM. Investigation of the antibacterial properties ofchitosan nanoparticles on Esherichia coli by qualitative agar well diffusion test and microdilution wasperformed to the concentration of 0.064 g/l to 0.256 g/l. The size of chitosan nanoparticles in this studywas 100 nm and spherical shape. The sizes of the inhibition zone were different according to the typeof bacteria and the concentrations of chitosan, the maximum zone diameter 20 mm in concentration0.256 g.l being observed.