Application of near-infrared responsive nano-carrier for controlled drug delivery: synthesis, isotherm and kinetic studies

Subject Areas : New Drug Delivery Systems

Mohammadreza  Mahdavijalal ¹ (Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran)
Homayon  Ahmad Panahi ² (Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran)
Ali  Niazi ³ (Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran)
Atefeh  Tamaddon ⁴ (Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran)
Elham  Moniri ⁵ (Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran)

Received: 2021-10-12 Accepted : 2021-12-26 Published : 2021-07-01

Keywords: Drug delivery, Thermo-sensitive polymer, Bicalutamide, In-vitro drug release, WS2 nano-sheets, Near-infrared light irradiation,

Abstract :

Due to the importance of selecting an appropriate strategy in drug delivery systems, numerous studies have been performed to support this process. However, there are still major obstacles associated with the targeted drug delivery to cancer tissues. Hence, the main focus of this study is to develop the current cancer therapies by using drug delivery systems. To achieve this goal, we have synthesized a near-infrared light responsive drug carrier based on WS2 nano-sheets, which can be a good candidate for applications such as drug delivery vehicle and chemo-photothermal treatments. In this study, a rapid and economy synthesis method was employed to modify the nano-sheets of WS2 for targeted drug delivery of bicalutamide as a prostate anti-cancer drug. The investigation of adsorption isotherm was fitted well by Langmuir model (qmax = 15.87 mg g-1). The evaluation of adsorption kinetic was better expressed by pseudo-second-order kinetic model (R2=0.9998). In-vitro drug release study was performed more rapid and complete in simulated blood fluid (pH=7.4) at 50°C than 37°C. Besides, the activity of the produced nano-carrier was examined under near-infrared light irradiation (at 808 nm). The drug release data were investigated through Zero-order, First-order, Higuchi, Hixson-Crowell and Korsmeyer–Peppas mathematical models.

References:

[1]        E. D. Crawford, “Epidemiology of prostate cancer,” Urology. Vol. 62, pp. 3-12, 2003.
[2]    I. D. Cockshott, “Bicalutamide, Clinical pharmacokinetics,” Springer, vol. 43, pp. 855–878, 2004.
[3]    S. Senapati, A. Kumar Mahanta, S. Kumar, and P. Maiti, “Controlled drug delivery vehicles for cancer treatment and their performance,” Signal Transduct Target Ther. Vol. 3, pp. 1-7, 2018.
[4]    Y. Lee and D. Thompson, “Stimuli‐responsive liposomes for drug delivery,” Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 9, pp. 1450 (1-76), 2017.
[5]    W. Paul and C. P. Sharma, “Inorganic nanoparticles for targeted drug delivery,” Biointegration of Medical Implant Materials, vol. 333, pp. 204-235, 2020.
[6]    J.P. Raval, P. Joshi, and D.R. Chejara, "Carbon nanotube for targeted drug delivery,” Applications of nanocomposite Materials in drug delivery: Elsevier, vol. 203, pp. 203-216, 2018.
[7]    Q. Zhou, L. Zhang, T.H. Yang, and H. Wu, “Stimuli-responsive polymeric micelles for drug delivery and cancer therapy,” International journal of nanomedicine. Vol.13 pp. 2921–2942, 2018.
[8]    M. Wu and S. Huang, “Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment,” Molecular and clinical oncology. Vol. 7, pp. 738–746, 2017.
[9]    Y. Yong, L. Zhou, Zh. Gu, L. Yan, G. Tian, X. Zheng, X. Liu, X. Zhang, J. Shi, W. Cong, W. Yin, and Y. Zhao “WS 2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells,” Nanoscale. Vol. 6, pp. 10394-10403, 2014.
[10]    Q. Liu, Ch. Sun, Q. He, A. Khalil, T. Xiang, D. Liu, Y. Zhou, J. Wang and L. Song, “Stable metallic 1T-WS 2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy,” Nano Research. Vol. 8, pp. 3982–3991, 2015.
[11]    M.J. Khodabakhshi, H. Ahmad Panahi, H. A. Panahi, E. Konoz, A. Feizbakhsh, and Salimeh Kimiagar, “NIR-triggered drug delivery system based on Fe3O4-MoS2 core-shell grafted poly (N-vinylcaprolactam): isotherm and kinetics studies,” Polymer-Plastics Technology and Materials. Vol.60, pp. 1247-1260, 2021.
[12]    H. Freundlich, “Über die adsorption in lösungen,” Zeitschrift für physikalische Chemie. Vol. 57, pp. 385-490, 1907.
[13]    I. Langmuir, “The adsorption of gases on plane surfaces of glass, mica and platinum,” Journal of the American Chemical society. Vol. 40, pp. 1361–1403, 1918.
[14]    M. Temkin, "The kinetics of some industrial heterogeneous catalytic reactions," Advances in Catalysis, vol. 28, pp. 173-291,1979.
[15]        O. Redlich and D. L. Peterson, “A useful adsorption isotherm,” Journal of physical chemistry. Vol. 63, pp. 1024, 1959.
[16]    Y.-S. Ho and G. McKay, “Pseudo-second order model for sorption processes,” Process biochemistry. Vol. 34, vol. 451-465,1999.
[17]    S. K. Lagergren, “About the theory of so-called adsorption of soluble substances,” Sven. Vetenskapsakad. Handingarl. Vol. 24, pp. 1-39, 1898.
[18]    W. J. Weber Jr and J. C. Morris, “Kinetics of adsorption on carbon from solution,” Journal of the sanitary engineering division. Vol. 89,  pp. 31-59, 1963.
[19]        Sh. Padash Hooshyar, R. Zafar Mehrabian, H. Ahmad Panahi, M. Habibi Jouybari, and H. Jalilian, “Synthesis and characterization of magnetized-PEGylated dendrimer anchored to thermosensitive polymer for letrozole drug delivery,” Colloids and Surfaces B: Biointerfaces. Vol. 176, pp. 404-411, 2019.
[20]    M. Gibaldi and S. Feldman, “Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms,” Journal of pharmaceutical sciences. Vol. 56 pp.1238-1242, 1967.
[21]    T. Higuchi, “Rate of release of medicaments from ointment bases containing drugs in suspension,” Journal of pharmaceutical sciences, Vol. 50, pp. 874-875, 1961.
[22]        T. Higuchi, “Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices,” Journal of pharmaceutical sciences, Vol. 52, pp. 1145-1149, 1963.
[23]    A. Hixson and J. Crowell, “Dependence of reaction velocity upon surface and agitation,” Industrial and Engineering Chemistry. Vol. 23, pp. 923–931, 1931.
[24]    C.G. Varelas, D.G. Dixon, and C.A. Steiner, “Zero-order release from biphasic polymer hydrogels,” Journal of controlled release. Vol. 34, pp. 185-192, 1995.
[25]    J. G. Wagner, “Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules,” Journal of pharmaceutical sciences, Vol. 58, pp.1253-1257, 1969.
[26]    R.W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, and N. A.Peppas, “Mechanisms of solute release from porous hydrophilic polymers,” International journal of pharmaceutics. Vol.15, pp.  25-35, 1983.
[27]    Z. Wu, D. Wang, X. Zan, and A. Sun, “Synthesis of WS2 nanosheets by a novel mechanical activation method,” Materials Letters.vol. vol. 64, pp. 856-858, 2010.
[28]    A. Bohloli, M.D. Asli, E. Moniri, and A.B. Gh, “Modification of WS 2 nanosheets with beta-cyclodextrone and N-isopropylacrylamide polymers for tamoxifen adsorption and investigation of in vitro drug release,” Research on Chemical Intermediates. Vol. 47, pp. 1955–1978, 2021.
[29]    N. Peppas, “Analysis of Fickian and non-Fickian drug release from polymers,” Pharmaceutica Acta Helvetiae.  Vol. 60, pp. 110-111, 1985.
[30]        P. L. Ritger and N. A. Peppas, “A simple equation for description of solute release II. Fickian and anomalous release from swellable devices,” Journal of controlled release. Vol. 5, pp. 37-42, 1987.