Investigating the effect of soluble and insoluble medicinal substances on cell wall orientation

Subject Areas : Biomedical Spectroscopy, Microscopy, Imaging, Endoscopy

Neda Ebrahimpour ^{1 *} , Mohammad Sadegh Zakerhamidi ² , Amid Ranjkesh ³ , Roshanak Kian ⁴

1 - Department of Chemical Industry, National University of Skills (NUS), Tehran, Iran
2 - Faculty of Physics, University of Tabriz, Tabriz, Iran
3 - Condenced Matter Department, J.Stefan Institute, Jmova 39, Ljubljana, Slovenia
4 - Faculty of Physics, University of Tabriz, Tabriz, Iran

Received: 2024-11-14 Accepted : 2025-01-26 Published : 2025-03-28

Keywords: Cell Wall, Liquid Crystal, Nanoparticle, Dielectric Constant, Refractive Index.,

Abstract :

Considering that the cell wall is the first defense and control barrier of medicinal substances into the cell, any dielectric behavior of this divider can lead to harm to the cell or the absorption of substances from the environment; hence, examining the dielectric and physicochemical behavior of the anisotropic cell wall is imperative. The present study employs 1102 (a mixture of liquid crystal) as an anisotropic environment, similar to the cell wall. Insoluble nanoparticle, Lithium disilicate (Li₂Si₂O₅) employed as non-reactive material, while materials containing active agents are used as soluble materials like Retinol (C₂₀H₃₀O). At various dopant concentrations, the dielectric characteristics and optical anisotropies of the liquid crystal and dopant mixture were observed, and the resulting data was analyzed and studied results indicate that the shape of the insoluble dopant influences the molecular order of the liquid crystal bulk, while for soluble substances, the percentage of dopant is more significant than the shape of dopants in the ordering of anisotropic media.

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