A Review on Bioactive Peptides and Their Potential Health Benefits and Applications in Poultry
Subject Areas :B. Navidshad 1 , M. Royan 2 , S. Karimzadeh 3
1 - Department of Animal Science, University of Mohaghegh Ardabili, Ardabil, Iran
2 - North Region Branch, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Rasht, Iran
3 - Department of Animal Science, Rodaki Higher Education Institute, Tonekabon, Mazandaran, Iran
Keywords: bioactive peptides, growth performance, gut health, immunomodulatory, poul-try,
Abstract :
Bioactive peptides are short chains of amino acids with specific biological activities, sourced from proteins in various natural sources such as food, animal tissues, and microbial cultures. They offer potential health benefits including antioxidant, antihypertensive, antimicrobial, and immunomodulatory activities. Re-searchers are exploring their potential applications in medicine alternatives to pharmaceutical drugs and antibiotics, as well as in the food industry as substitutes for synthetic additives. Bioactive peptides can be derived from a diverse array of natural sources including milk, eggs, fish, plants, and microbial proteins, making them a promising area of research. In poultry nutrition, bioactive peptides have demonstrated re-markable benefits. They exhibit antimicrobial activity, which contributes to better gut health and reduced risk of infections. Additionally, they can enhance growth performance by improving nutrient absorption and utilization, and may play a role in alleviating stress in poultry, leading to improved overall health and per-formance. Various studies have highlighted the positive effects of bioactive peptides derived from different sources such as soybean, cottonseed, and canola meal on broiler growth, feed conversion ratio, and health indicators. The potential of bioactive peptides as functional nutrients in poultry nutrition and health man-agement is indeed promising.
Abdollahi M.R., Zaefarian F., Gu Y., Xiao W., Jia J. and Ravindran V. (2017). Influence of soybean bioactive pep-tides on growth performance, nutrient utilisation, diges-tive tract development and intestinal histology in broilers. J. Appl. Anim. Nutr. 5, 7-13.
Abdollahi M.R., Zaefarian F., Gu Y., Xiao W., Jia J. and Ravindran V. (2018). Influence of soybean bioactive pep-tides on performance, foot pad lesions and carcass charac-teristics in broilers. J. Appl. Anim. Nutr. 6, 3-9.
Adler-Nissen J. (1986). Enzymic Hydrolysis of Food Pro-teins. Applied Science Publishers, Elsevier, London, United Kingdom.
Akbarian M., Khani A., Eghbalpour S. and Uversky V.N. (2022). Bioactive peptides: Synthesis, sources, applica-tions, and proposed mechanisms of action. Int. J. Mol. Sci. 23, 1445-1455.
Alahyaribeik S., Nazarpour M., Tabandeh F., Honarbakhsh S. and Sharifi S.D. (2022). Effects of bioactive peptides de-rived from feather keratin on plasma cholesterol level, lipid oxidation of meat, and performance of broiler chicks. Trop. Anim. Health Prod. 54, 271-279.
Aslam S., Shukat R., Khan M.I. and Shahid M. (2020). Effect of dietary supplementation of bioactive peptides on anti-oxidant potential of broiler breast meat and physico-chemical characteristics of nuggets. Food Sci. Anim. Re-sour. 40, 55-62.
Bahadori M.M., Rezaeipour V., Abdullahpour R. and Irani M. (2022). Effects of sesame meal bioactive peptides, in-dividually or in combination with a mixture of essential oils, on growth performance, carcass, jejunal morphology, and microbial composition of broiler chickens. Trop. Anim. Health Prod. 54, 235-241.
Bruno B.J., Miller G.D. and Lim C.S. (2013). Basics and recent advances in peptide and protein drug delivery. Ther. Deliv. 4, 1443-1467.
Crantz F.R., Swartz S.L., Hollenberg N.K., Moore T.J., Dluhy R.G. and Williams G.H. (1980). Differences in re-sponse to the peptidyldipeptide hydrolase inhibitors SQ 20,881 and SQ 14,225 in normal-renin essential hyperten-sion. Hypertension. 2, 604-609.
Daliri E.B.M., Lee B.H. and Oh D.H. (2018). Current trends and perspectives of bioactive peptides. Crit. Rev. Food Sci. Nutr. 58, 2273-2284.
Garcés-Rimón M., Morales D. and Miguel-Castro M. (2022). Potential role of bioactive proteins and peptides derived from legumes towards metabolic syndrome. Nutrients. 14, 5271-5279.
Goldstein A., Tachibana S., Lowney L.I., Hunkapiller M. and Hood L. (1979). Dynorphin-(1-13), an extraordinarily po-tent opioid peptide. Proc. Natl. Acad. Sci. 76, 6666-6670.
Harnedy P.A. and FitzGerald R.J. (2012). Bioactive peptides from marine processing waste and shellfish: A review. J. Funct. Foods. 4, 6-24.
Hartmann R. and Meisel H. (2007). Food-derived peptides with biological activity: from research to food applica-tions. Curr. Opin. Biotechnol. 18, 163-169.
Hernández-Ledesma B. and Hsieh C.C. (2013). Bioactive Food Peptides in Health and Disease. BoD–Books on Demand, Norderstedt, Germany.
Hosseinpoor L., Navidshad B., Faseleh Jahromi M., Karimzadeh S., Kalantari Hesari A., Mirzaei Agh-jehgheshlagh F. and Heydari A. (2023). The antioxidant properties of bioactive peptides derived from enzymatic hydrolyzed or fermented canola meal and its effects on broiler chickens. Int. J. Pept. Res. Ther. 29, 40-49.
Hughes J. (1975). Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 88, 295-308.
Jeske S., Zannini E. and Arendt E.K. (2018). Past, present and future: The strength of plant-based dairy substitutes based on gluten-free raw materials. Food Res. Int. 110, 42-51.
Karimzadeh S., Rezaei M. and Yansari A.T. (2017). Effects of different levels of canola meal peptides on growth per-formance and blood metabolites in broiler chickens. Livest. Sci. 203, 37-40.
Klompong V., Benjakul S., Kantachote D. and Shahidi F. (2007). Antioxidative activity and functional properties of protein hydrolysate of yellow stripe trevally (Selaroides leptolepis) as influenced by the degree of hydrolysis and enzyme type. Food Chem. 102, 1317-1327.
Landy N., Kheiri F. and Faghani M. (2020). Evaluation of cottonseed bioactive peptides on growth performance, carcase traits, immunity, total antioxidant activity of se-rum and intestinal morphology in broiler chickens. Italian J. Anim. Sci. 19, 1375-1386.
Liu J., Luo Y., Zhang X., Gao Y. and Zhang W. (2022). Ef-fects of bioactive peptides derived from cottonseed meal solid-state fermentation on the growth, metabolism, and immunity of yellow-feathered broilers. Anim. Sci. J. 93, 1-9.
López-Pedrouso M., Zaky A.A., Lorenzo J.M., Camiña M. and Franco D. (2023). A review on bioactive peptides de-rived from meat and by-products: Extraction methods, biological activities, applications and limitations. Meat Sci. 204, 109278-109288.
Meisel H. (1997). Biochemical properties of bioactive pep-tides derived from milk proteins: potential nutraceuticals for food and pharmaceutical applications. Livest. Prod. Sci. 50, 125-138.
Minamino N., Kangawa K., Fukuda A., Matsuo H. and Iaga-rashi M. (1980). A new opioid octapeptide related to dynorphin from porcine hypothalamus. Biochem. Biophys. Res. Commun. 95, 1475-1481.
Minkiewicz P., Iwaniak A. and Darewicz M. (2019). BIO-PEP-UWM database of bioactive peptides: Current oppor-tunities. Int. J. Mol. Sci. 20, 5978-5987.
Mohammadrezaei M., Navidshad B., Gheisari A. and Toghy-ani M. (2021). Cottonseed meal bioactive peptides as an alternative to antibiotic growth promoters in broiler chicks. Int. J. Pept. Res. Ther. 27, 329-340.
Parvez M.A.K., Jubyda F., Ayaz M., Sarker A., Haque N., Khan S., Mou T., Rahman M. and Huq, M. (2024). Mi-crobial and plant-derived bioactive peptides and their ap-plications against foodborne pathogens: Current status and future prospects. Int. J. Microbiol. 2024, 1-29.
Pert C.B. and Snyder S.H. (1973). Opiate receptor: Demon-stration in nervous tissue. Science. 179, 1011-1014.
Rizwan D., Masoodi F.A., Wani S.M. and Mir S.A. (2023). Bioactive peptides from fermented foods and their rele-vance in COVID-19 mitigation. Food Prod. Proc. Nutr. 5, 53-62.
Salavati M.E., Rezaeipour V., Abdullahpour R. and Mousavi S.N. (2021). Bioactive peptides from sesame meal for broiler chickens: Its influence on the serum biochemical metabolites, immunity responses and nutrient digestibil-ity. Int. J. Pept. Res. Ther. 27, 1297-1303.
Salavati M.E., Rezaeipour V., Abdullahpour R. and Mousavi N. (2020). Effects of graded inclusion of bioactive pep-tides derived from sesame meal on the growth perform-ance, internal organs, gut microbiota and intestinal mor-phology of broiler chickens. Int. J. Pept. Res. Ther. 26, 1541-1548.
Sholikin M.M., Irawan A., Prihambodo T.R., Qomariyah N., Wahyudi A.T., Nomura J. and Jayanegara A. (2021a). Antimicrobial peptides as an additive in broiler chicken nutrition: a meta-analysis of bird performance, nutrient digestibility and serum metabolites. J. Anim. Feed Sci. 30, 100-110.
Sholikin M.M., Wahyudi A.T., Jayanegara A., Nomura J. and Nahrowi N. (2021b). A meta-analysis of antimicrobial peptide effects on intestinal bacteria, immune response, and antioxidant activity of broilers. Trop. Anim. Sci. J. 44, 188-197.
Toldrá F. (2010). Handbook of Meat Processing. John Wiley & Sons, Blackwell Publishing, New York.
Udenigwe C.C. and Aluko R.E. (2012). Food protein-derived bioactive peptides: production, processing, and potential health benefits. J. Food Sci. 77, 11-24.
Xuan J., Feng W., Wang J., Wang R., Zhang B., Bo L. and Sun L. (2023). Antimicrobial peptides for combating drug-resistant bacterial infections. Drug. Resist. Updat. 68, 1-8.
Wang G., Li X. and Wang Z. (2016). APD3: the antimicro-bial peptide database as a tool for research and education. Nucleic Acids. Res. 44, 1087-1093.
Zhao X., Zhang Y., He W., Wei Y., Han S., Xia L. and Cui C. (2022). Effects of small peptide supplementation on growth performance, intestinal barrier of laying hens dur-ing the brooding and growing periods. Front. Immunol. 13, 1-10.