Alfacalcidol (1-Alpha-Hydroxycholecalciferol) and Its Efficacy in Broiler Nutrition
Subject Areas : CamelN. Landy 1 , F. Kheiri 2 , A. Kamyab 3
1 - Department of Animal Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
2 - Department of Animal Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
3 - Department of Animal Science, University of Missouri, Columbia, 65211, USA
Keywords: broiler chickens, phytase, Cholecalciferol, alfacalcidol, phytate phosphorus,
Abstract :
Alfacalcidol (1-alpha-hydroxycholecalciferol) is a synthetic analog of vitamin D. This medicine has been considered as a precursor for calcitriol (1, 25-dihydroxyvitamin D3) which alters to calcitriol after hydroxylation. Alfacalcidol is one of the most effective compounds that enter the body and can be converted to an active form and be effective in conditions that the body is challenged with vitamin D insufficiency or hypocalcemia. The clinical benefits of alfacalcidol are relevant to stimulating the absorption of calcium and phosphorus, improving muscle functions, and improving bone mineralization. Several studies have been conducted regarding the supplementation of alfacalcidol in broiler chickens diet. In summary, results of some studies revealed that the effectiveness of alfacalcidol significantly decreases with the increase in dietary calcium level. This vitamin D metabolite not only acts by hydrolyzing phytate molecules in a phytase-like manner, but also enhances the utilization of phytate phosphorus in other procedures. Also, results of a research trial showed that the best results regarding performance criteria and bone tissue formation in broiler chickens eventuated when 5 μg of alfacalcidol and 1500 IU of cholecalciferol/kg of diet were supplemented to diet.
Akiba T., Marumo F., Owada A., Kurihara S., Inoue A., Chida Y., Ando R., Shinoda T., Ishida Y. and Ohashi Y. (1998). Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Am. J. Kidney Dis. 32, 238-246.
Biehl R.R., Baker D.H. and DeLuca H.F. (1998). Activity of various hydroxylated vitamin D3 analogs for improving phosphorus utilization in chicks receiving diets adequate in vitamin D3. British Poult. Sci. 39, 408-412.
Biehl R.R., Baker D.H. and DeLuca H.F. (1995). 1α-Hydroxylated cholecalciferol compounds act additively with microbial phytase to improve phosphorus, zinc and manganese utilization in chicks fed soy-based diets. J. Nutr. 125, 2407-2416.
Biehl R.R. and Baker D.H. (1997). Utilization of phytate and non-phytate phosphorus in chicks as affected by source and level of vitamin D3. J. Anim. Sci. 75, 2986-2993.
Boris A., Hurley J.F. and Trmal T. (1977). Relative activities of some metabolites and analogs of cholecalciferol in stimulation of tibia ash weight in chicks otherwise deprived of vitamin D. J. Nutr. 107, 194-198.
Diaz M. (2018). Effects of 1-alpha-hydroxycholecaciferol and other vitamin D analogs on live performance, bone development, meat yield and quality, and mineral digestibility on broilers. Which university? Which city? Which country?.
Driver J.P., Pesti G.M., Bakalli R.I. and Edwards Jr H.M. (2005). Phytase and 1α-hydroxycholecalciferol supplementation of broiler chickens during the starting and growing/finishing phases. Poult. Sci. 84, 1616-1628.
Dollery C. (1999). Therapeutic Drugs. Churchill-Livingston, Edinburgh, Scotland, United Kingdom.
Edwards H.M. (1993). Dietary 1, 25-dihydroxycholecalciferol supplementation increases natural phytase utilization in chickens. J. Nutr. 123, 567-577.
Edwards H.M., Shirley R.B., Escoe W.B. and Pesti G.M. (2002). Quantitative evaluation of 1-α-hydroxycholecalciferol as a cholecalciferol substitute for broilers. Poult. Sci. 81, 664-669.
Ghasemi P., Toghyani M. and Landy N. (2019). Effects of dietary 1-alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens. Anim. Nutr. 5, 134-139.
Halabe A., Arie R., Mimran D., Samuel R. and Liberman U. (1994). Hypoparathyroidism–a long-term follow-up experience with 1-alpha-vitamin D3 therapy. Clin. Endocrinol. 40, 303-307.
Han J.C., Yang X.D., Zhang L.M., Li W.L., Zhang T., Zhang Z.Y. and Ya J.H. (2009). Effects of 1α-Hydroxycholecalciferol and phytase on growth performance, tibia parameter and meat quality of 1- to 21-d-old broilers. Asian Australasian J. Anim. Sci. 22, 857-864.
Han J., Liu Y., Yao J., Wang J., Qu H., Yan Y., Yue J., Ding J., Shi Z. and Dong X. (2012a). Dietary calcium levels reduce the efficacy of 1-alpha-hydroxycholecalciferol in phosphorus-deficient diets of broilers. J. Poult. Sci. 49, 34-38.
Han J.C., Wang Y.L., Qu H.X., Liang F., Zhang J.L., Shi C.X., Zhang X.L., Li L., Xie Q., Wang C.L., Yan Y.Y., Dong X.S., and Cheng Y.H. (2012b). One alpha-hydroxycholecalciferol improves growth performance, tibia quality, and meat color of broilers fed calcium- and phosphorus-deficient diets. Asian Australasian J. Anim. Sci. 25, 267-271.
Haussler M.R., Zerwekh J.E., Hesse R.H., Rizzardo E. and Pechet M.M. (1973). Biological activity of 1alpha-hydroxycholecalciferol, a synthetic analog of the hormonal form of vitamin D3. Proc. Nat. Acad. Sci. 70, 2248-2252.
Holick M., de Blanco M., Clark M., Henley J., Neer R., Deluca H. and Potts J.T. (1977). The metabolism of 1alpha, hydroxycholecalciferol to 1alpha, 25-dihydroxycholecalciferol in a patient with renal insufficiency. J. Clin. Endocrinol. Metab. 44, 595-598.
Joffe P., Cintin C., Ladefoged S.D. and Rasmussen S.N. (1994). Pharmacokinetics of 1-alpha-hydroxycholecalciferol after intraperitoneal, intravenous and oral administration in patients undergoing peritoneal dialysis . Clin. Nephrol. 41, 364-369.
Kheiri F. and Landy N. (2019). The effects of dietary 1-alpha-hydroxycholecalciferol individually or in combination with different levels of cholecalciferol on growth performance and tibia criteria in broiler chickens. Livest. Sci. 221, 172-176.
Kheiri F., Jalali Haji Abadi S.M.A., Poshtvar M. and Landy N. (2019). Influence of dietary 1-alpha-hydroxycholecalciferol, individually or in combination with microbial phytase in calcium and phosphorus deficient diets on performance and tibia parameter of Japanese quails (Coturnix japonica). Acta Sci. Anim. Sci. 41, e42540.
Landy N. and Toghyani M. (2014). Evaluation the effects of dietary cholecalciferol substitution with 1alpha-hydroxycholecalciferol on performance and tibia parameters in broiler chickens. Int. J. Poult. Sci. 13, 515-517.
Landy N., Toghyani M., Bahadoran M. and Eghbalsaied S. (2015). The effects of 1alpha-hydrox-ycholecalciferol supplementation on performance and tibia parameter of broiler chickens. Res. Opin. Anim. Vet. Sci. 5, 342-347.
Landy N. and Toghyani M. (2017). Evaluation of 1-alpha-hydroxycholecalciferol alone or in combination with cholecalciferol in Ca and P deficiency diets on development of tibial dyschondroplasia in broiler chickens. Anim. Nutr. 4, 109-112.
Landy N., Kheiri F., Faghani M. and Bahadoran R. (2021). Investigation of different levels of cholecalciferol and its metabolite in calcium and phosphorus deficient diets on growth performance, tibia bone ash and development of tibial dyschondroplasia in broilers. Acta Sci. Anim. Sci. 43, e48816.
Ledwaba M.F. and Roberson K.D. (2003). Effectiveness of twenty five hydroxycholecalciferol in the prevention of tibial dyschondro plasia in Ross cockerels depends on dietary calcium level. Poult. Sci. 82, 1769-1777.
Mitchell R.D. and Edwards H.M. (1996). Effects of phytase and 1,25-dihydroxycholecalciferol on phytate utilization and the quantitative requirement for calcium and phosphorus in young broiler. Poult. Sci. 75, 95-110.
Muraki K., Nishi Y., Tsuda K., Yoshimitsu K. and Usui T. (1983). A case of hypophosphatemic vitamin D-resistant rickets treated with initial massive dose of 1-alpha-hydroxy-vitamin D3 alone. Acta Paediatr. Scandinavica. 72, 763-768.
Nelson T.S., Shieh T.R., Wodzinski R.J. and Ware J.H. (1971). Effect of supplemental phytase on the utilization of phytate phosphorus by chicks. J. Nutr. 101, 1289-1294.
Nishii Y. (2003). Rationale for active vitamin D and analogs in the treatment of osteoporosis. J. Cell. Biochem. 88, 381-386.
Shams S.H., Kheiri F. and Landy N. (2022). The effects of 1-alpha-hydroxycholecalciferol individually or in combination with phytase, and different levels of cholecalciferol on performance, tibia criteria, and plasma minerals of Japanese quails. Acta Sci. Anim. Sci. 44, e54218.
Simons P.C.M., Versteegh H.A.J., Joengbloed A.W., Kemme P.A., Slump P., Bos K.D., Wolters M.G.E., Beudeker R.F. and Vershoor G.J. (1990). Improvement of phosphorus availability by microbial phytase in broilers and pigs. British J. Nutr. 64, 525-540.
Skelly A., Dettori J. and Brodt E. (2012). Assessing bias: the importance of considering confounding. Evid. Based Spine. Care. J. 3, 9-12.
Snow J.L., Baker D.H. and Parsons C.M. (2004). Phytase, citric acid, and 1α-hydroxycholecalciferol improve phytate phosphorus utilization in chicks fed a corn-soybean meal diet. Poult. Sci. 83, 1187-1192.
Soares J.H., Kerr J.M. and Gray R.W. (1995). 25-hydroxycholecalciferol in poultry nutrition. Poult. Sci. 74, 1919-1934.
Sweetman S.C. (2002). Martindale: The Complete Drug Reference. Pharmaceutical Press, London, United Kingdom.
Vervloet M. (2014). Clinical uses of 1-alpha-hydroxycholecalciferol. Curr. Vasc. Pharmacol. 12, 300-305.
Warren M., Vu T., Toomer O., Fernandez J. and Livingston K. (2020). Efficacy of 1-α-hydroxycholecalciferol supplementation in young broiler feed suggests reducing calcium levels at grower phase. Front. Vet. Sci. 7, 245-255.