Vicia variabilis a Nutritive Feed for Domesticated Animals: A Survey about Cytotoxic and Antioxidant Activity

Subject Areas : Camel

M. Mosaddegh ¹ (Traditional Medicine and MateriaMedicaResearchCenter, ShahidBeheshtiUniversityof Medical Science, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy, ShahidBeheshtiUniversityof Medical Science, Tehran, Iran)
M. Hamzeloo Moghadam ² (Traditional Medicine and MateriaMedicaResearchCenter, ShahidBeheshtiUniversityof Medical Science, Tehran, IranDepartment of Traditional Pharmacy, School of Traditional Medicine, ShahidBeheshtiUniversityof Medical Science, Tehran, Iran)
F. Naghibi ³ (Traditional Medicine and MateriaMedicaResearchCenter, ShahidBeheshtiUniversityof Medical Science, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy, ShahidBeheshtiUniversityof Medical Science, Tehran, Iran)
S. Mohebby ⁴ (Food and Drug Organization, Tehran, Iran)
A. Pirani ⁵ (Traditional Medicine and MateriaMedicaResearchCenter, ShahidBeheshtiUniversityof Medical Science, Tehran, Iran)
B. Eslami ⁶ (Traditional Medicine and MateriaMedicaResearchCenter, ShahidBeheshtiUniversityof Medical Science, Tehran, Iran)

Received: 2011-09-30 Accepted : 2011-10-21 Published : 2012-09-01

Keywords: Antioxidant Activity, Cytotoxicity, domesticated animals, MTT Assay, <i>Vicia variabilis</i>,

Abstract :

Safety and beneficence of farm animal nutrition plays a great role in their healthy life which in turn have impact on human nutrition via diary or meat products. Assessing safety and beneficence of Vicia varibilis Freyn and Sint. Which is chosen intrinsically by domesticated animals of Kohgiluyehand Boyerahmad Iranis the aim of the present work. Our results not only show no cytotoxic activity in 3-(4,5-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide(MTT) assay but also admit the antioxidant activity of the species through scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals confirmed in DPPH assay.

References:

Alley M.C., Scudiero D.A., Monkes A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H. and Boyd M.R (1988). Feasibility of drug screening with panel of human tumor cell lines using a microculture tetrazolium assay. Cancer. Res. 48, 589-601.
MilanS. (2006) Spice antioxidants isolation and their antiradical activity: A review. J. Food Comp. Anal. 19, 531-537.
Mohammadi Motamed S. and Naghibi F. (2010). Antioxidant activity of some edible plants of the Turkmen Sahra region in northern Iran. Food Chem. 119, 1637-1642.
Molyneux P. (2004). The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J. Sci. Tech. 26, 211-219.
Mosaddegh M., Hamzeloo Moghadam M., Ghafari S., Naghibi F., Ostad S.N. and Read R.W. (2010). Sesquiterpene lactones from Inula oculus-christi. Nat. Prod. Com. 5(4), 511-514.
Pakravan M., Jalilian N. and Nemati M. (2000). Flora of Iran. Research Institute of Forests and Rangelands, 33, 96-106. Tehran, Iran.
Rahimifard N., Hajimehdipoor H., Hedayati M.H., Bagheri O. and Pishehvar A. (2010). Cytotoxic effects of essential oils and extracts of some Mentha species on Vero, Hela and Hep2 cell lines. J. Med. Plants. 9(35), 88-92.
Sharif Ali S., Kasoju N., Luthra A., Singh A., Sharanabasava H., Sahu A. and Bora U. (2008). Indian medicinal herbs as source of antioxidants. Food Res. Int. 41, 1-15.
Statistical Centre of Iran.(2011).No.1 (5/27/2012). http://www.amar.org.ir.
Tripathi R., Mohan H. and Kamat J.P. (2007). Modulation of oxidative damage by natural products. Food Chem. 100, 81-90.
Vundać V.B., Brantner A.H. and Plazibat M. (2007). Content of polyphenolic constituents and antioxidant activity of some Stachys taxa. Food Chem. 104, 1277-1281.