The Effect of Underlying Diseases on Kidney Transplant Survival Rate
Subject Areas : Health Management
Ghahreman Mahmoudi
1
,
Mohammad Ali Jahani
2
,
Alireza Moradi Lanjevani
3
*
1 - Hospital Administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran
2 - Associate professor of Babol University of Medical Sciences
3 - Department of health services management, Sar.C.,Islamic Azad University, Sari, Iran.
Keywords: Transplant survival, Kidney transplant, Graft rejection, Underlying disease.,
Abstract :
Background and Aim: Identifying factors affecting kidney transplant survival in patients with end-stage renal disease is essential to improve transplant survival and improve the kidney transplant process. This study aimed to determine the effect of underlying diseases on kidney transplant survival rates in transplant recipients from living donors at Farhangian Hospital.
Materials and Methods: This cross-sectional and retrospective study was conducted on 700 patients who underwent kidney transplantation in Farihectan Hospital between April 2020 and September 2023. Sampling was based on a census, and researcher-made demographic information questionnaires and inpatient files of transplant patients were used to collect data. Kaplan-Meier, Cox regression, and log-rank tests were utilized to estimate survival rates and identify the impact of underlying diseases on transplant survival using SPSS version 23. The significance level of the tests was considered smaller than 0.05.
Results: The Kaplan-Meier method estimated the
1-year, 2-year, 3-year, and 4-year transplant survival rates at 94.71%, 86.4%, 81.1%, and 77.0%, respectively. The Cox regression model demonstrated that recipient age (P ˂0.05), donor age (P ˂0.05), and the presence of diabetes and hypertension as underlying diseases (P ˂0.001) significantly affected kidney transplant survival rates.
Conclusion: The transplant survival rate in Farhikhtegan Hospital was higher than in the past years and in some of the country's major transplant centers. Therefore, it seems necessary to pay attention to other factors affecting graft survival rates in addition to the present ones.
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