The effect of aerobic exercise on insulin sensitivity in brown adipose tissue

Subject Areas : Exercise Physiology and Performance

Farnaz Sahebi ¹ , Mohammad Ali Azarbayjani ^{2 *} , Sirvan Atashak ³ , Maghsoud Peeri ⁴ , Saleh Rahmati-Ahmadabad ⁵

1 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
3 - Department of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran
4 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
5 - Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran

Received: 2024-09-12 Accepted : 2024-10-05 Published : 2024-10-10

Keywords: Brown adipose tissue, aerobic exercise, insulin sensitivity, GDF15,

Abstract :

In order to reduce obesity complications, brown adipose tissue (BAT) plays a very important role. This tissue increases energy consumption through thermogenesis by absorbing and oxidizing glucose and fatty acids. It controls weight and reduces obesity. Physical activities, especially aerobic exercise, can reduce obesity by improving BAT function. Despite the contradictory results evidence shows that aerobic exercise enhances glucose uptake and oxidation in BAT by enhancing insulin sensitivity. Aerobic exercise increases insulin sensitivity by stimulating beta-adrenergic receptor activity and stimulating the production and release of growth differentiation factor 15 (GDF15) and prevents hyperglycemia complications caused by inactivity. Based on this, it is determined that the improvement of insulin sensitivity in brown fat tissue is one of the mechanisms justifying the positive effect of aerobic exercise on reducing obesity complications, which shows the importance of brown fat tissue in health development.

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