Valine Consumption And Endurance Exercise Modified The Inflammation In Rat Model Of Anxiety/Depression.

Subject Areas : Exercise Physiology and Performance

Mohammad-Hossein Beigi ¹ ( Silicon Hall: Micro/Nano Manufacturing Facility, Faculty of Engineering and Applied Science, Ontario Tech University, Ontario, Canada. )

Received: 2022-08-26 Accepted : 2023-02-13 Published : 2023-04-01

Keywords: Endurance training, Brain, anxiety, Depression Valine,

Abstract :

Background: Depression and anxiety are disabling conditions with side effects on cognition, quality of life, memory, and mood. Anxiety is a dysregulated mood condition that could disturb cognition. The present study aimed to evaluate the effect of dietary interventions and endurance training in managing anxiety and depressive symptoms.Methods: In this study, 30 rats were divided into five groups: Normal group, anxiety/ depression group, rat model of anxiety/depression who consumed valine 3.0 μmol/500 μl intraperitoneal injection once/day for eightweeks, rat model of anxiety/depression who conducted endurance training (32 m/min for 45 minutes/session, six days a week for eight weeks), and rat model of anxiety/depression who conducted endurance training (75% VO2max) and consumed valine (3.0 μmol/500 μl). The level of anxiety/depression was evaluated by behavior open field tests and relative expression assay of the genes related to the inflammation.Results: Findings indicated that the expression level of the NF-κB and TNFα significantly increased in the anxiety/depression group. Moreover, the endurance training and consumed valine improved the NF-κB and TNFα expression in the brain of the rat model of anxiety/depression. In addition, endurance training and consuming valine decreased the anxiety/depression level.Conclusion: Endurance training and consuming valine reduced the brain's inflammation level and improved the anxiety/depression level.

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