آرایه‌های میکروسوزن: مروری بر اصول، کاربردها و پیشرفت‌های اخیر
محورهای موضوعی : کاربرد شیمی در محیط زیست
noushin dadashzadeh
1
*
,
الناز پوررضا
2
,
ناصر مصلحی میلانی
3
1 - Department of physics, Faculty of physics,Hadishahr Branch, Islamic Azad University, Hadishahr, Iran.
2 - گروه آموزشی برق، دانشگاه آزاد اسلامی واحد ارس، شهر جلفا، ایران
3 - گروه فیزیک، واحد اهر، دانشگاه آزاد اسلامی، اهر، ایران
کلید واژه: آرایه میکروسوزن, انتقال پوستی دارو, میکروسوزن جامد, میکروسوزن خالی, میکروسوزن متخلخل, میکروسوزن قابل حل, میکروسوزن متورم,
چکیده مقاله :
آرایه‌های میکروسوزن (MNA) ابزارهای نوآورانه‌ای هستند که از سوزن‌های ریز در ابعاد چند ده میکرون تا چند میلی‌متر تشکیل شده‌اند. این ریزساختارها که از مواد مختلفی مانند فلزات، پلیمرها، سرامیک‌ها و مواد زیست‌سازگار ساخته می‌شوند، کاربردهای گسترده‌ای را در زمینه‌های مختلف پزشکی به ارمغان آورده‌اند. MNAها با نفوذ به لایه‌های بالایی پوست یا بافت‌های دیگر، روش‌های نوینی را برای انتقال دارو، واکسیناسیون، نمونه برداری و تشخیص بیماری‌ها ارائه می‌دهند.
در این مطالعه تلاش خواهیم کرد تا با بهره‌گیری از تحقیقات روز دنیا و جزئیات بیشتر، اطلاعات دقیق‌تری را درباره میکرونیدل‌ها و کاربردهای آنها در حوزه‌های زیبایی‌شناسی، پزشکی و سایر زمینه‌ها بدست آوریم. به علاوه، نقاط ضعف و چالش‌هایی که در استفاده از این فناوری وجود دارد نیز بررسی و تحلیل می‌شوند تا در آینده بتوانیم از میکروسوزن‌ها بهره بیشتری ببریم و نقاط قوت آنها را بهبود دهیم. همچنین، بررسی دقیق‌تر و دسته‌بندی بهتر انواع میکروسوزن‌ها و تاثیرات آنها بر روی پوست و بافت‌های تحت تأثیر آنها نیز به دلیل اهمیت‌شان در استفاده از این فناوری صورت خواهد گرفت. در نهایت با ترکیب داده‌ها و نتایج بدست آمده راهکارهای بهبود و ارتقای استفاده از میکروسوزن‌ها و توسعه‌ی کاربردهای جدید در این حوزه را خواهیم داشت.
Microneedle Arrays (MNA( are innovative devices composed of tiny needles with dimensions ranging from tens of micrometers to a few millimeters. These microstructures, fabricated from various materials such as metals, polymers, ceramics, and biocompatible materials, have opened up a wide range of applications in various medical fields. By penetrating the upper layers of the skin or other tissues, MNAs offer novel methods for drug delivery, vaccination, sampling, and disease diagnosis. In this study, we will strive to gain a more detailed understanding of microneedles and their applications in the fields of aesthetics, medicine, and other areas by utilizing the latest research and providing more in-depth information. Additionally, the limitations and challenges associated with this technology will be examined and analyzed to enable us to make better use of microneedles in the future and enhance their strengths. Furthermore, a more thorough examination and categorization of microneedle types and their effects on the skin and underlying tissues will be conducted due to their significance in the application of this technology. Finally, by combining the data and findings obtained, we will be able to develop strategies for improving and enhancing the use of microneedles and expanding their applications in this field.
Scheuplein, R.J.; Blank, I.H. Permeability of the skin. Physiol. Rev. 1971, 51, 702–747.[1]
[۲] Singh, T.; Mcmillan, H.; Mooney, K.; Alkilani, A.; Donnelly, R. Microneedles for drug delivery and monitoring. Microfluid. Devices Biomed. Appl. 2013, 185–230, doi:10.1533/9780857097040.2.185.
[3] Donnelly, R.F.; Singh, T.R.R.; Larrañeta, E.; McCrudde, M.T.C. Microneedles for Drug and Vaccine Delivery and Patient Monitoring; John Wiley and Sons, Incorporated: Hoboken, NJ, USA, 2018.
[4] Walsh, L. Microneedling: A versatile and popular treatment option. J. Aesthetic Nurs. 2019, 8, 280–284.
[5] Chambers, R. Microdissection studies, III. some problems in the maturation and fertilization of the echinoderm egg. Biol. Bull. 1921, 41, 318–350.
[6] Larraneta, E.; Lutton, R.E.M.; Woolfson, A.D.; Donnelly, R.F. Microneedle Arrays As Transdermal and Intradermal Drug Delivery Systems: Materials Science, Manufacture and Commercial Development; Elsevier: Amsterdam, The Netherlands, 2016, 104, 1-32
[7]. Gerstel, M.S.; Place, V.A. Drug Delivery Device. U.S. Patent US3964482A, 22 June 1976, 3, 964, 482.
[8]. Reed, M.; Lye, W.-K. Microsystems for Drug and Gene Delivery. Proc. IEEE 2004, 92, 56–75.
[9] Prausnitz, M.R.; Langer, R. Transdermal drug delivery. Natl. Inst. Health 2009, 26, 1261–1268.
[10] Orentreich, D.S.; Orentreich, N. Subcutaneous Incisionless (Subcision) Surgery for the Correction of Depressed Scars and Wrinkles. Dermatol. Surg. 1995, 21, 543–549.
[11] Henry, S.; McAllister, D.V.; Allen, M.G.; Prausnitz, M.R. Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery. J. Pharm. Sci. 1998, 87, 922–925.
[12] Prausnitz, M.R. Microneedles for transdermal drug delivery. Adv. Drug Deliv. Rev. 2004, 56, 581–587.
[13] Dang, N.; Liu, T.Y.; Prow, T.W. Nano-and Microtechnology in Skin Delivery of Vaccines. In Micro and Nanotechnology in Vaccine Development; William Andrew Publishing: Norwich, NY, USA, 2017.
[14] Johnson, A.R.; Procopio, A.T. Low cost additive manufacturing of microneedle masters. 3D Print. Med. 2019, 5, 2.
[15] Krieger, K.J.; Bertollo, N.; Dangol, M.; Sheridan, J.T.; Lowery, M.M.; O’Cearbhaill, E.D. Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing. Microsyst. Nanoeng. 2019, 5, 42.
[16] Haj-Ahmad R., Khan H., Arshad M.S., Rasekh M., Hussain A., Walsh S., Li X., Chang M.-W., Ahmad Z. Microneedle Coating Techniques for Transdermal Drug Delivery. Pharmaceutics. 2015;7:486–502. doi: 10.3390/pharmaceutics7040486.
[17] Wang B.Z., Gill H.S., He C., Ou C., Wang L., Wang Y.-C., Feng H., Zhang H., Prausnitz M.R., Compans R.W. Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity. J. Control. Release. 2014;178:1–7. doi: 10.1016/j.jconrel.2014.01.002.
[18] Waghule, T.; Singhvi, G.; Dubey, S.K.; Pandey, M.M.; Gupta, G.; Singh, M.; Dua, K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomed. Pharmacother. 2018, 109, 1249–1258.
[19] Kim, Y.C.; Park, J.H.; Prausnitz, M.R. Microneedles for drug and vaccine delivery. Drug Deliv. Transl. Res. 2015, 5, 311–312.
[20] Al-Zahrani S., Zaric M., McCrudden C., Scott C., Kissenpfennig A., Donnelly R.F. Microneedle-mediated vaccine delivery: Harnessing cutaneous immunobiology to improve efficacy. Expert Opin. Drug Deliv. 2012;9:541–550. doi: 10.1517/17425247.2012.676038.
[21] Jacoby, E.; Jarrahian, C.; Hull, H.F.; Zehrung, D. Opportunities and Challenges in Deliveringinfluenza Vaccineby Microneedle Patch; Elsevier: Amsterdam, The Netherlands, 2015; p. 20892.
[22] Norman J.J., Arya J.M., McClain M.A., Frew P.M., Meltzer M.I., Prausnitz M.R. Microneedle patches: Usability and acceptability for self-vaccination against influenza. Vaccine. 2014;32:1856–1862. doi: 10.1016/j.vaccine.2014.01.076.
[23] Gardeniers H.J.G.E., Luttge R., Berenschot E.J.W., de Boer M.J., Yeshurun S.Y., Hefetz M., van’t Oever R., van den Berg A. Silicon micromachined hollow microneedles for transdermal liquid transport. J. Microelectromech. Syst. 2003;12:855–862. doi: 10.1109/JMEMS.2003.820293.
[24] Cheung, K.; Das, D.B. Microneedles for drug delivery: Trends and progress. Drug Deliv. 2014, 23, 2338–2354.
[25] Ita, K. Transdermal Delivery of Drugs with Microneedles—Potential and Challenges. Pharmaceutics 2015, 7, 90–105.
[26] Sanjay, S.T.; Dou, M.; Fu, G.; Xu, F.; Li, X. Controlled Drug Delivery Using Microdevices Sharma. Curr. Pharm. Biotechnol. 2017, 25, 1032–1057.
[27] Donnelly, R.F.; Morrow, D.I.J.; McCrudden, M.T.C.; Alkilani, A.Z.; Vicente-Pérez, E.M.; O'Mahony, C.; González-Vázquez, P.; McCarron, P.; Woolfson, A.D. Hydrogel-Forming and Dissolving Microneedles for Enhanced Delivery of Photosensitizers and Precursors. Photochem. Photobiol. 2014, 90, 641–647.
[28] Mishra, R.; Bhattacharyya, T. MEMS-based hollow microneedles for transdermal drug delivery. Drug Deliv. Devices Ther. Syst. 2020, 325–344, doi:10.1016/b978-0-12-819838-4.00007-9.
[29] Zhang, P.; Dalton, C.; Jullien, G.A. Design and fabrication of MEMS-based microneedle arrays for medical applications. Microsyst. Technol. 2009, 15, 1073–1082.
[30] McAllister, D.V.; Wang, P.M.; Davis, S.P.; Park, J.-H.; Canatella, P.J.; Allen, M.G.; Prausnitz, M.R. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies. Proc. Natl. Acad. Sci. USA 2003, 100, 13755–13760
[31] Khanna P., Luongo K., Strom J.A., Bhansali S. Axial and shear fracture strength evaluation of silicon microneedles. Microsyst. Technol. 2010;16:973–978. doi: 10.1007/s00542-010-1070-4.
[32] Gittard S., Chen B., Xu H., Ovsianikov A., Chichkov B.N., Monteiro-Riviere N.A., Narayan R.J. The Effects of Geometry on Skin Penetration and Failure of Polymer Microneedles. J. Adhes. Sci. Technol. 2013;27:227–243. doi: 10.1080/01694243.2012.705101.
[33] Park J.H., Allen M.G., Prausnitz M.R. Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. J. Control. Release. 2005;104:51–66. doi: 10.1016/j.jconrel.2005.02.002.
[34] Demir, Y.K.; Akan, Z.; Kerimoglu, O. Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery. PLoS ONE 2013, 8, e77289.
[35] Rodgers, A.M.; Cordeiro, A.S.; Donnelly, R.F. Technology update: Dissolvable microneedle patches for vaccine delivery. Med Devices 2019, 12, 379–398.
[36] Guillot, A.J.; Cordeiro, A.S.; Donnelly, R.F.; Montesinos, M.C.; Garrigues, T.M.; Melero, A. Microneedle-Based Delivery: An Overview of Current Applications and Trends. Pharmaceutics 2020, 12, 569.
[37]González-Vázquez, P.; Larrañeta, E.; McCrudden, M.T.; Jarrahian, C.; Rein-Weston, A.; Quintanar-Solares, M.; Zehrung, D.; McCarthy, H.; Courtenay, A.J.; Donnelly, R.F. Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis. J. Control. Release 2017, 265, 30–40.
[38] Liu S., Jin M.N., Quan Y.S., Kamiyama F., Kusamori K., Katsumi H., Sakane T., Yamamoto A. Transdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skin. Eur. J. Pharm. Biopharm. 2014;86:267–276. doi: 10.1016/j.ejpb.2013.10.001.
[39] Chang H., Zheng M., Yu X., Than A., Seeni R.Z., Kang R., Tian J., Khanh D.P., Liu L., Chen P., et al. A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis. Adv. Mater. 2017;29:1702243. doi: 10.1002/adma.201702243.
[40]Jeggy, C. Micro-Injection Moulding: From Process to Modelling; Presses Univ. de Louvain: Louvain-la-Neuve, Belgium, 2004Jeggy, C. Micro-Injection Moulding: From Process to Modelling; Presses Univ. de Louvain: Louvain-la-Neuve, Belgium, 2004.
[41]Monteiro-Riviere, N.A. Toxicology of the Skin; CRC Press: New York, NY, USA, 2010.
[42] Yuan, W.; Hong, X.; Wu, Z.; Chen, L.; Liu, Z.; Wu, F.; Wei, L.L. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des. Dev. Ther. 2013, 7, 945–952.
[43] Niinomi, M.; Nakai, M. Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone. Int. J. Biomater. 2011, 2011, 836587.
[44] Donnelly, A.D.W.R.F.; Singh, T.R.R.; Morrow, D.I.J. Microneedle-Mediated Transdermal and Intradermal Drug Delivery; John Wiley & Sons: Hoboken, NJ, USA, 2012.
[45] Sharma, D. Microneedles: An Approach in Transdermal Drug Delivery: A Review. PharmaTutor 2018, 6, 7–15.
[46] Badilescu, S.; Packirisamy, M. BioMEMS: Science and Engineering Perspectives; CRC Press: Boca Raton, FL, USA, 2016.
[47] O’Mahony, C. Structural characterization and in-vivo reliability evaluation of silicon microneedles. Biomed. Microdevices 2014, 16, 333–343.
[48] Pignatello, R. Biomaterials: Applications for Nanomedicine; BoD–Books on Demand: Rijeka, Croatia, Norderstedt, Germany, 2011.
[49] Indermun, S.; Luttge, R.; Choonara, Y.; Kumar, P.; du Toit, L.; Modi, G.; Pillay, V. Current advances in the fabrication of microneedles for transdermal delivery. J. Control. Release 2014, 185, 130–138.
[50] Bystrova, S.; Luttge, R. Micromolding for ceramic microneedle arrays. Microelectron. Eng. 2011, 88, 1681–1684.
[51] Adarkwa, E.; Desai, S. Scalable Droplet Based Manufacturing Using In-Flight Laser Evaporation. J. Nanoeng. Nanomanuf. 2016, 6, 87–92.
[52] Nejad, H.R.; Sadeqi, A.; Kiaee, G.; Sonkusale, S. Low-cost and cleanroom-free fabrication of microneedles. Microsyst. Nanoeng. 2018, 4, 17073.
[53] Chen, Y.-T.; Ma, K.-J.; Tseng, A.A.; Chen, P.-H. Projection ablation of glass-based single and arrayed microstructures using excimer laser. Opt. Laser Technol. 2005, 37, 271–280.
[54] Zheng, H.; Lam, Y.; Sundarraman, C.; Tran, D. Influence of substrate cooling on femtosecond laser machined hole depth and diameter. Appl. Phys. A 2007, 89, 559–563.
[55] Lutton, R.; Larrañeta, E.; Kearney, M.-C.; Boyd, P.; Woolfson, A.; Donnelly, R.F. A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays. Int. J. Pharm. 2015, 494, 417–429.
[56] Zaied, M.; Miraoui, I. Analysis of heat affected zone obtained by CO2 laser cutting of low carbon steel (S235). In AIP Conference Proceedings; American Institute of Physics: College Park, MD, USA, 2013.
[57] Brookhaven National Laboratory. Femtosecond Laser Micromachining. In Ultrafast Nonlinear Optics; Springer: Berlin/Heidelberg, Germany, 2013.
[58] Gaikwad, A.; Desai, S. Molecular Dynamics Investigation of the Deformation Mechanism of Gold with Variations in Mold Profiles during Nanoimprinting. Materials 2021, 14, 2548.
[59] Plummer, J.D.; Deal, M.D.; Griffin, P.B. Silicon VLSI Technology: Fundamentals, Practice and Modeling; Pearson Education: India, 2009.
[60] Tran, K.T.; Nguyen, T.D. Lithography-based methods to manufacture biomaterials at small scales. J. Sci. Adv. Mater. Devices 2017, 2, 1–14.
[61] Lee, K.; Lee, H.C.; Lee, D.-S.; Jung, H. Drawing Lithography: Three-Dimensional Fabrication of an Ultrahigh-Aspect-Ratio Microneedle. Adv. Mater. 2010, 22, 483–486.
[62] Griffiths, C.A. Micro Injection Moulding: Tooling and Process Factors; Cardiff University: Cardiff, UK, 2008.
[63] Kim, M.J.; Park, S.C.; Rizal, B.; Guanes, G.; Baek, S.-K.; Park, J.-H.; Betz, A.R.; Choi, S.-O. Fabrication of Circular Obelisk-Type Multilayer Microneedles Using Micro-Milling and Spray Deposition. Front. Bioeng. Biotechnol. 2018, 6, 54.
[64] Park, J.-H.; Allen, M.G.; Prausnitz, M.R. Biodegradable polymer microneedles Fabrication, mechanics andtransdermal drug delivery. J. Control. Release 2005, 104, 51–66.
[65] Lhernould, M.S.; Deleers, M.; Delchambre, A. Hollow polymer microneedles array resistance and insertion tests. Int. J. Pharm. 2015, 480, 152–157.
[66] Nair, K.J. Micro-Injection Moulded Microneedles for Drug Delivery; University of Bradford: Bradford, UK, 2014.
[67] Sammoura, F.; Kang, J.; Heo, Y.-M.; Jung, T.; Lin, L. Polymeric microneedle fabrication using a microinjection molding technique. Microsyst. Technol. 2006, 13, 517–522.
[68] Juster, H.; van der Aar, B.; de Brouwer, H. A review on microfabrication of thermoplastic polymer-based microneedle arrays. Polym. Eng. Sci.2019, 59, 877–890.
[69] Parupelli, S.K.; Desai, S. A Comprehensive Review of Additive Manufacturing (3D Printing): Processes, Applications and Future Potential. Am. J. Appl. Sci. 2019, 16, 244–272.
[70] Aldawood, F.K.; Desai, S.; Chang, S. Additive Manufacturing of Compensator Devices for Radiation Therapy. In Proceedings of the 2012 IISE Annual Conference, Virtual Conference, 1–3 November 2020.
[71] Aldawood, F.K.; Chang, S.X.; Desai, S. Design and manufacture of a high precision personalized electron bolus device for radiation therapy. Med. Devices Sensors 2020, 3, doi:10.1002/mds3.10077.
[72] Haeberle, G.; Desai, S. Investigating Rapid Thermoform Tooling Via Additive Manufacturing (3d Printing). Am. J. Appl. Sci. 2019, 16, 238–243.
[73] Pere, C.P.P.; Economidou, S.N.; Lall, G.; Ziraud, C.; Boateng, J.S.; Alexander, B.D.; Lamprou, D.; Douroumis, D. 3D printed microneedles for insulin skin delivery. Int. J. Pharm. 2018, 544, 425–432.
[74] . Lee, J.W.; Choi, S.-O.; Felner, E.I.; Prausnitz, M.R. Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone. Small 2011, 7, 531–539.
[75] Dangol, M.; Kim, S.; Li, C.G.; Lahiji, S.F.; Jang, M.; Ma, Y.; Huh, I.; Jung, H. Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patchin high-fat diet-induced obese C57BL:6J mice. J. Control. Release 2017, 265, 41–47.
[76] Tas, C.; Mansoor, S.; Kalluri, H.; Zarnitsyn, V.G.; Choi, S.-O.; Banga, A.K.; Prausnitz, M.R. Delivery of salmon calcitonin using a microneedle patch. Int. J. Pharm. 2012, 423, 257–263.
[77] Matriano, J.A.; Cormier, M.; Johnson, J.; Young, W.A.; Buttery, M.; Nyam, K.; Daddona, P.E. Macroflux® Microprojection Array Patch Technology: A New and Efficient Approach for Intracutaneous Immunization. Pharm. Res. 2002, 19, 63–70.
[78] Donnelly, R.F.; Morrow, D.I.J.; McCarron, P.; Woolfson, A.D.; Morrissey, A.; Juzenas, P.; Juzeniene, A.; Iani, V.; McCarthy, H.; Moan, J. Microneedle Arrays Permit Enhanced Intradermal Delivery of a Preformed Photosensitizer. Photochem. Photobiol. 2009, 85, 195–204.
[79] Stahl, J.; Wohlert, M.; Kietzmann, M. Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points. BMC Pharmacol. Toxicol. 2012, 13, 5.
[80] Nayak, S.; Suryawanshi, S.; Bhaskar, V. Microneedle Technology for Transdermal Drug Delivery: Applications and Combination With Other Enhancing Techniques. J. Drug Deliv. Ther. 2016, 6, 65–83, doi:10.22270/jddt.v6i5.1285.
[81] Stoeber, B.; Liepmann, D. Fluid injection through out-of-plane microneedles. In Proceedings of the 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings, Lyon, France, 12–14 October 2000; pp. 224–228.
[82] Chen, J.; Wise, K.D.; Hetke, J.F.; Bledsoe, S.C. A multichannel neural probe for selective chemical delivery at the cellular level. IEEE Trans. Biomed. Eng. 1997, 44, 760–769.
[83] Marshall, S.; Sahm, L.J.; Moore, A. The success of microneedle-mediated vaccine delivery into skin. Hum. Vaccines Immunother. 2016, 12, 2975–2983, doi:10.1080/21645515.2016.1171440.
[84] Matsuo, K.; Hirobe, S.; Yokota, Y.; Ayabe, Y.; Seto, M.; Quan, Y.S.; Kamiyama, F.; Tougan, T.; Horii, T.; Mukai, Y.; et al. Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J. Control. Release 2012, 160, 495–501.
[85] Yang, J.; Liu, X.; Fu, Y.; Song, Y. Recent advances of microneedles for biomedicalapplications- drug delivery and beyond.pdf. Acta Pharm. Sin. B 2019, 9, 469–483.
[86] Poirier, D.; Renaud, F.; Dewar, V.; Strodiot, L.; Wauters, F.; Janimak, J.; Shimada, T.; Nomura, T.; Kabata, K.; Kuruma, K.; et al. Hepatitis B surface antigen incorporated in dissolvable microneedle array patch is antigenic and thermostable. Biomaterials 2017, 145, 256–265.
[87] Pattani, A.; McKay, P.; Garland, M.J.; Curran, R.M.; Migalska, K.; Cassidy, C.M.; Malcolm, K.; Shattock, R.J.; McCarthy, H.; Donnelly, R.F. Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations. J. Control. Release 2012, 162, 529–537.
[88] Edens, C.; Dybdahl-Sissoko, N.C.; Weldon, W.C.; Oberste, M.S.; Prausnitz, M.R. Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque. Vaccine 2015, 33, 4683–4690.
[89] Hiraishi, Y.; Nandakumar, S.; Choi, S.-O.; Lee, J.W.; Kim, Y.-C.; Posey, J.E.; Sable, S.B.; Prausnitz, M.R. Bacillus CalmetteGuérin vaccination using a microneedle patch. Vaccine 2011, 29, 2626–2636.
[90] Gill, H.S.; Söderholm, J.; Prausnitz, M.R.; Sällberg, M. Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther. 2010, 17, 811–814.
[91] Zhu, Q.; Zarnitsyn, V.G.; Ye, L.; Wen, Z.; Gao, Y.; Pan, L.; Skountzou, I.; Gill, H.S.; Prausnitz, M.R.; Yang, C.; et al. Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc. Natl. Acad. Sci. USA 2009, 106, 7968–79739.
[92] Mikszta, J.A.; Dekker, J.P.; Harvey, N.G.; Dean, C.H.; Brittingham, J.M.; Huang, J.; Sullivan, V.J.; Dyas, B.; Roy, C.; Ulrich, R.G. Microneedle-Based Intradermal Delivery of the Anthrax Recombinant Protective Antigen Vaccine. Infect. Immun. 2006, 74, 6806–6810.
[93] . Huang, J.; D'Souza, A.J.; Alarcon, J.B.; Mikszta, J.A.; Ford, B.M.; Ferriter, M.S.; Evans, M.; Stewart, T.; Amemiya, K.; Ulrich, R.G.; et al. Protective Immunity in Mice Achieved with Dry Powder Formulation and Alternative Delivery of Plague F1-V Vaccine. Clin. Vaccine Immunol. 2009, 16, 719–725.
[94] Van Damme, P.; Oosterhuis-Kafeja, F.; van der Wielen, M.; Almagor, Y.; Sharon, O.; Levin, Y. Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults. Vaccine 2009, 27, 454–459.
[95] Zhu, J.; Zhou, X.; Libanori, A.; Sun, W. Microneedle-based bioassays. Nanoscale Adv. 2020, 2, 4295–4304.
[96] Chang, H.; Zheng, M.; Yu, X.; Than, A.; Seeni, R.Z.; Kang, R.; Tian, J.; Khanh, D.P.; Liu, L.; Chen, P.; et al. A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis. Adv. Mater. 2017, 29, 1–8.
[97] Kim, J.-Y.; Han, M.-R.; Kim, Y.-H.; Shin, S.-W.; Nam, S.-Y.; Park, J.-H. Tip-loaded dissolving microneedles for transdermal delivery of donepezil hydrochloride for treatment of Alzheimer’s disease. Eur. J. Pharm. Biopharm. 2016, 105, 148–155.
[98] Wang, P.M.; Cornwell, M.; Prausnitz, M.R. Minimally Invasive Extraction of Dermal Interstitial Fluid for Glucose Monitoring Using Microneedles. Diabetes Technol. Ther. 2005, 7, 131–141.
[99] O’Mahony, C.; Pini, F.; Vereschagina, L.; Blake, A.; O’Brien, J.; Webster, C.; Galvin, P.; McCarthy, K.G. Skin insertion mechanisms of microneedle-based dry electrodes for physiological signal monitoring. In Proceedings of the 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS), Rotterdam, The Netherlands, 31 October–2 November 2013, pp. 69–72.
[100] Mohan, A.V.; Windmiller, J.R.; Mishra, R.K.; Wang, J. Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays. Biosens. Bioelectron. 2017, 91, 574–579.
[101] Sharma, S.; Hatware, K.; Bhadane, P.; Sindhikar, S.; Mishra, D.K. Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies. Mater. Sci. Eng. C 2019, 103, 109717.
[102] Park, Y.-H.; Ha, S.K.; Choi, I.; Kim, K.S.; Park, J.; Choi, N.; Kim, B.; Sung, J.H. Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery. Biotechnol. Bioprocess Eng. 2016, 21, 110–118.
[103] Kumar, A.; Naguib, Y.; Shi, Y.-C.; Cui, Z. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016, 23, 1495–1501.
[104] Mysore, V.; Chandrashekar, B.; Yepuri, V. Alopecia areata-successful outcome with microneedling and triamcinolone acetonide. J. Cutan. Aesthetic Surg. 2014, 7, 63–64.
[105] Majid, I. Microneedling therapy in atrophic facial scars: An objective assessment. J. Cutan. Aesthetic Surg. 2009, 2, 26–30.
[106] El-Domyati, M.; Barakat, M.; Awad, S.; Medhat, W.; El-Fakahany, H.; Farag, H. Microneedling therapy for atrophic acne scars an objective evaluation. J. Clin. Aesthet. Dermatol. 2015, 8, 36–42.
[107] Aust, M.C.; Knobloch, K.; Reimers, K.; Redeker, J.; Ipaktchi, R.; Altintas, M.A.; Gohritz, A.; Schwaiger, N.; Vogt, P.M. Percutaneous collagen induction therapy: An alternative treatment for burn scars. Burns 2010, 36, 836–843.
[108] Dhurat, R.; Sukesh, M.; Avhad, G.; Dandale, A.; Pal, A.; Pund, P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study. Int. J. Trichology 2013, 5, 6–11.
[109] Economidou, S.N.; Douroumis, D. 3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential. Adv. Drug Deliv. Rev. 2021, 173, 60–69.
[110] Bhatnagar, S.; Gadeela, P.R.; Thathireddy, P.; Venuganti, V.V.K. Microneedle-based drug delivery: Materials of construction. J. Chem. Sci. 2019, 131, 90.
[111] Desai, S.; Perkins, J.; Harrison, B.S.; Sankar, J. Understanding release kinetics of biopolymer drug delivery microcapsules for biomedical applications. Mater. Sci. Eng. B Solid-State Mater. Adv. Technol. 2010, 168, 127–131.
[112] Li, Q.Y.; Zhang, J.N.; Chen, B.Z.; Wang, Q.L.; Guo, X.D. A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin. RSC Adv. 2017, 7, 15408–15415.
[113] Al-Japairai, K.A.S.; Mahmood, S.; Almurisi, S.H.; Venugopal, J.R.; Hilles, A.R.; Azmana, M.; Raman, S. Current trends in polymer microneedle for transdermal drug delivery. Int. J. Pharm. 2020, 587, 119673–119673.