Green synthesis of morpholine-2-thione by multicomponent reaction of aziridines

Subject Areas : Iranian Journal of Organic Chemistry

Narges Ghasemi ^{1 *} , Samaneh sadat Sharifi ²

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Received: 2023-09-17 Accepted : 2023-09-17 Published : 2023-08-01

Keywords: multi component reaction, Aziridin, Carbone disulfide, Nitro methane,

Abstract :

A series of substituted morpholine-2-thione derivatives were synthesized via one-pot multicomponent reactions of nitromethane, carbon disulfide and aziridine in the presence of Et3N under solvent-free conditions. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.