بررسی اثر یک دوره تمرین هوازی و مکمل سیر بر ساختار بافت قلب در موش های چاقDOR: 20.1001.1.17359880.1400.14.3.6.7
محورهای موضوعی : مجله پلاسما و نشانگرهای زیستی
آسیه عباسی دلویی
1
(استادیار فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران)
هدا تابع
2
(گروه تربیت‌بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد آیت الله آملی، آمل، ایران)
سید جواد ضیاءالحق
3
(گروه فیزیولوژی ورزشی واحد شاهرود، دانشگاه آزاد اسلامی ، شاهرود، ایران.)
علیرضا براری
4
(گروه فیزیولوژی ورزشی واحد آیت الله آملی، دانشگاه آزاد اسلامی ، آمل، ایران.)
کلید واژه: چاقی, سیر, بافت قلب, موش‌های صحرایی, تمرین,
چکیده مقاله :
زمینه و هدف: اصلاح شیوه زندگی شامل فعالیت بدنی و مصرف مکمل های گیاهی بخش مهمی در سلامت، پیشگیری و درمان چاقی بوده و با کاهش عوارض قلبی عروقی ناشی از چاقی همراه است. هدف از این تحقیق، بررسی اثر یک دوره تمرین هوازی و مکمل سیر بر ساختار بافت قلب در موش های چاق می باشد.روش کار: در این مطالعه تجربی، 25سر رت نر(5سر رت سالم بالغ و 20سر رت نر بالغ چاق نژاد ویستار) به طور تصادفی در پنج گروه کنترل(سالم)، چاق، چاق-سیر، چاق-تمرین هوازی و چاق-سیر-تمرین هوازی قرار گرفتند. گروه های مکمل طی دوره مداخله مکمل سیر را به میزان 250میلی گرم به ازای هرکیلوگرم وزن بدن به صورت گاواژ روزانه دریافت کردند. تمرین هوازی روی تردمیل، 5 روز در هفته به مدت هشت هفته اجرا شد. پس از بیهوشی، کالبد شکافی انجام و بافت قلب برداشته و ﻣﺘﻐﻴﺮﻫﺎی ﻣﻮرد ارزﻳﺎﺑﻲ در ﺑﺎﻓﺖ ﻗﻠﺐ ﺷﺎﻣﻞ ﺗﻐﻴﻴﺮات ﺑﺎﻓﺖ ﻗﻠﺐ، ﺳﻠﻮل ﻫﺎی ﻋﻀﻼﻧﻲ، ﻧﻜﺮوز، اﻟﺘﻬﺎب و ﭘﺮﺧﻮﻧﻲ بود ﻛـﻪ ﺷﺪت و درﺟﻪ ﺗﻐﻴﻴﺮات ﻣﺬﻛﻮر ﺑﺮاﺳﺎس ﻣﺸﺎﻫﺪات ﻣﻴﻜﺮوﺳـﻜﻮﭘﻴﻚ و ﺗﻬﻴﻪ ﻓﺘﻮﻣﻴﻜﺮوﮔﺮاف ﺻﻮرت ﮔﺮﻓﺖ.یافته ها: در موش های چاق تغییرات پاتولوژیک بافتی عضله قلب و سلول های قلبی در مقایسه با گروه کنترل مشاهده شد. تمرین هوازی و مصرف سیر هر کدام به تنهایی موجب کاهش تغییرات پاتولوژیک بافتی عضله قلب و سلول های قلبی بود. هم چنین، تعامل تمرین هوازی و مصرف مکمل سیر با بهبود تغییرات بافتی و سلولی در بافت قلب همراه گشته بود.نتیجه گیری: با توجه به نتایج، تمرین هوازی به همراه مکمل سیر احتمالاً می تواند به بهبود تغییرات ساختار بافت قلب طی چاقی کمک کند.
Inroduction & Objective: Lifestyle modification, including physical activity and the use of herbal supplements, is an important part of the health, prevention and treatment of obesity and it’s associated with reduction in cardiovascular complications caused by obesity. The aim of this study was to evaluate the effect of aerobic training and garlic supplementation on heart tissue structure in obese rats.Material and Method: To implementation of this experimental research, 25 male rats (5 healthy adult rats and 20 adults obese male Wistar rats) were randomly divided into five groups: control (healthy), obese, obese-garlic, obese-aerobic training and obese-garlic. Aerobic exercises were performed. Supplement groups received garlic supplementation at rate of 250 mg per kg body weight as daily gavage during the intervention period. Aerobic exercise was performed on treadmill, 5 days week for eight weeks. After anesthesia, an autopsy was performed and heart tissue was removed. The changes of heart tissue, Muscle cells, necrosis, inflammation and hyperemia were assessed, the severity and degree of these changes were performed based on microscopic and photomicrographs observations.Results: The results showed that in obese rat’s pathological changes of heart muscle and heart cells were observed in comparison with the control group. Aerobic training and consumption of garlic reduced pathological changes in heart muscle tissue and heart cells. Also, the interaction of aerobic training and garlic supplementation was associated with the improvement of tissue and cellular changes in heart tissue. Conclusion: According to the results, aerobic training with garlic supplementation can probably help improve changes in the structure of heart tissue during obesity.
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