Effect of eight weeks low intensity aerobic exercise on endothelin-1 plasma level, blood pressure and heart rate in healthy people and patients with coronary artery disease

محورهای موضوعی : Report of Health Care

Amin Mehrabi ¹ , Farhad Daryanoosh ² , Maryam Amirazodi ³ , Mohammad Ali Babaee Baigi ⁴ , Kouros Divsalar ⁵

1 - MA of Exercise Physiology, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2 - Associate Professor, Department of Exercise Physiology, Shiraz University, Shiraz, Iran
3 - PhD Candidate, Department of exercise physiology, International Devision of Shiraz University, Shiraz, Iran| Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4 - Department of heart and vascular, Shiraz University of Medical Sciences, Shiraz, Iran
5 - MSc, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

تاریخ دریافت : 1394/02/17 تاریخ پذیرش : 1394/03/31 تاریخ انتشار : 1394/03/11

کلید واژه: aerobic exercise, Endothelin-1, Heart rate, Blood pressure, Coronary Artery Disease,

چکیده مقاله :

Introduction: Cardiovascular homeostasis such as tonicity of vessels and blood flow can be affected by activities and hormones. The purpose of the present study was to investigate the effect of 8 weeks low intensity aerobic exercise on plasma endothelin-1 (ET-1), blood pressure and heart rate (HR) in healthy men and women and coronary artery disease (CAD) patients.
Methods: In this quasi-experimental study, the experimental group consisted of 30 CAD patients (15 males and 15 females). The control group included 15 healthy males and 15 healthy females. These groups were chosen randomly. Participants did aerobic exercises with the intensity of 30%-40% of maximum HR. Blood samples were taken from participants in three stages (before, immediately and 24 hours after 8 weeks of exercise) and ET-1 plasma level was measured by ELISA method.
Results: There was no significant alteration in ET-1 plasma level during the experiment. However, there was a significant difference in the systolic blood pressure (SBP) at the three stages in all groups (P = 0.01). In addition, we could observe a significant difference in the diastolic blood pressure (DBP) at the three stages in CAD men and healthy women (P = 0.03). Conversely, no significant difference was observed in the DBP of other groups. There was a significant difference in the blood pressure of three groups (P = 0.002) except for healthy men.
Conclusion: The results demonstrated that, as there is a threshold in terms of time or intensity to stimulate the secretion of hormone; when the intensity and duration of exercise is below the stimulation threshold, no significant change can be observed in the level of ET-1.

منابع و مأخذ:

1. Nazar ali P. Advanced Cardiovascular Exercise Physiology. Tehran: Hatmi publications, Inc; 2011. p. 139-50. [In Persian].

2. Dargahi L. Historical review: endothelin. Razi Journal 2008; 19(4): 24-32. [In Persian]

3. Hickey KA, Rubanyi G, Paul RJ, Highsmith RF. Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 1985; 248(5 Pt 1): C550-6.

4. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. Novel potent vasoconstricotr peptide prodced by vacular endothelial cells. Nature 1988; 332(6163): 411-5.

5. Kedzierski RM, Yanagisawa M. Endothelin system the double-edged sword in health and dicease. Annu Rev Pharmacol Toxicol 2001; 41: 851-76.

6. Gray MO, Long CS, Kalinyak JE, Li HT, Karliner JS. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. Cardiovasc Res 1998; 40(2): 352-63.

7. Stewart DJ, Kubac G, Costello KB, Cernacek P. Increased plasma endothelin-1 in the early hours of acute myocardial infarction. J Am Coll Cardiol 1991; 18(1): 38-43.

8. Maeda S, Miyauchi T, Kakiyama T, Sugawara J, Iemitsu M, Irukayama-Tomobe Y, et al. Effects of exercise traninig of 8 weeks and detraning of plasma livels of endothelium-derived factors, endothelin-1 and nitric oxid, in healty young humans. Life Sci 2001; 69(9): 1005-16.

9. Maeda S, Miyauchi T, Goto K, Matsuda M. Alteration of plasma endothielin-1 by exercise at intensities lower and higher than ventilatory threshold. J Appl Physiol (1985) 1994; 77(3): 1399-402.

10. Kopeć G, Tyrka A, Miszalski-Jamka T, Mikołajczyk T, Waligóra M, Guzik T, et al. Changes in exercise capacity and cardiac performance in a series of patients with Eisenmenger’s syndrome transitioned from selective to dual endothelin receptor antagonist. Heart Lung Circ 2012; 21(11): 671-8.

11. Boghrabadi V, Hejazi SM, Peeri M, Nejatpour S. The effect of aerobic exercise on endohelin-1 concentration in old

women atherosclerosis suplements. Ofogh-e-Danesh 2012; (17)4: 69-76. [Persian]

12. Maeda S, Miyauchi T, Iemitsu M, Sugawara J, Nagata Y, Goto K. Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans. J Cardiovasc Pharmacol 2004; 44 Suppl 1: S443-6.

13. Cosenzi A, Sacerdote A, Bocin E, Molino R, Plazzotta N, Seculin P, et al. Neither physical exercise nor α1 and beta-adrenergic blockade affect plasma enothilin concentrations. Am J Hypertens 1996; (9)8: 819-22.

14. Callaerts-Végh Z, Wenk M, Goebbels U, Dziekan G, Myers J, Dubach P, et al. Influence of intensive physical traning of uriyary nitrate elimination and plasma endothelin-1 levels in patients with congestive heart failure. J Cardiopulm Rehabil 1998; 18(6): 450-7.

15. Genth-Zotz S, Zotz RJ, Cobaugh M, van Veldhuisen DJ, Netzer T, Meyer J, et al. Chenges of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure. Int J Cardiol 1998; 66(2): 137-42.

16. Donato AJ, Lesniewski LA, Delp MD. The effects of aging and exercise tranining of endothelin-1 vasoconstrictor Response in rat skeletal muscle arterioles. Cardiovasc Res 2005; 66(2): 393-401.

17. Ahmadiasl N, Niknazar S, Farajnia S, Alipour MR. The effects of three months exersice on expression of endothelin-1 in the lung tissue. Pharm Sci 2008; 8(3): 59-62. [In Persian]

18. Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, et al. Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J Appl Physiol (1985) 2003; 95(1): 336-41.

19. Attipoe S. The influence of ECE-1 gene polymorphsm and exercise traning on plams and urinary edothelin-1 levels in pre-and stage 1 hypertensives. USA: UMI; 2007. p. 60-4.