اثر تعاملی یک دوره تمرين هوازی اینتروال و آلفالیپوئیک اسید بر سطوح آیریزین، ویسفاتین و مقاومت به انسولین در موشهاي دیابتی
محورهای موضوعی : اثر فعالیت بدنی بر بیماری هامحمدمهدی جعفری 1 , امین فرزانه حصاری 2 , نیلوفر دستجردی شاحسین 3
1 -
2 - Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
3 - گروه تربیت بدنی، واحد ساری، دانشگاه آزاد اسلامی
کلید واژه: دیابت, تمرین هوازی اینتروال, آنتی اکسیدان, آیریزین, ویسفاتین,
چکیده مقاله :
زمینه و هدف: مداخله ورزشی و دارویی مخصوصاً داروهاي گیاهی، از جمله بهترین رویکردهاي بهبود وضعیت در افراد دیابتی محسوب می¬شود. ازطرفی، آلفالیپوئیک اسید یک آنتی¬اکسیدان بیولوژیکی قوی است. بااین حال، اثر همزمان تمرین ورزشی و آلفالیپوئیک اسید بر دیابت بخوبی مشخص نیست. هدف از مطالعه¬ی حاضر بررسی تأثیر هشت هفته تمرین هوازی اینتروال با شدت متوسط و مصرف آلفالیپوئیک اسید بر مقادیر آیریزین، ویسفاتین و مقاومت به انسولین در موشهای دیابتی نوع دو بود. مواد و روشها: در این مطالعه تجربی، 42 سر موش نر بطور تصادفی به 6 گروه (سالم، دیابتی، سالین، تمرین، مکمل، مکمل+ تمرین) قرار گرفتند. دیابت با تزریق درون صفاقی استرپتوزوتوسین القا شد. گروه¬های تمرینی به مدت هشت هفته، سه جلسه در هفته و هرجلسه شامل 10 وهله یک دقیقه¬ای دویدن روی ترمیل با شدت 70 درصد اکسیژن مصرفی با دو دقیقه استراحت بین ستها را اجرا کردند. آلفالیپوئیک اسید به مقدار mg/kg20 در روز بصورت گاواژ به موشها داده شد. از روش آماری تحیلیل واریانس یکطرفه و سطح معناداری 05/0 ≥α استفاده شد. یافته¬ها: یافته¬ها نشان داد که آیریزین افزایش معناداری در گروه‌های مکمل، تمرین و تمرین + مکمل نسبت به گروه دیابتی داشت (001/0P=). میزان ویسفاتین (021/0P=)، میزان گلوگز (011/0P=) و مقاومت به انسولین (008/0P=) در گروه-های تمرین و مکمل+تمرین کاهش معنی¬داری نسبت به گروه دیابت داشت. نتیجه¬گیری: به نظر می¬رسد که تمرین هوازی اینتروال با شدت متوسط به همراه با مصرف آلفالیپوئیک اسید می¬تواند با افزایش آیریزین و کاهش ویسفاتین، گلوگز و مقاومت انسولین تاثیر مثبت بر کنترل دیابت نوع دو بگذارد.
Background and Objectives: Exercise training and drug interventions, especially herbal medicines, are considered as best approaches to improving the health status of diabetic patients. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of this study was to investigate the effect of moderate-intensity interval training and ALA supplementation on serum irisin, visfatin and insulin resistance in type 2 diabetic rats. Materials and Methods: In this experimental study, 42 Wistar rats (average and age of 12 weeks and weight of 230 ±8 grams) were randomly assigned to 6 groups: control, diabetic, salin, supplementation, training and training+supplementation. Diabetes was induced by intra-peritoneal injection of streptozotocin. The training program included 8 weeks, three sessions per week, and each session with 10 periods of one minutes activity at 70% maximum speed and two minute rest. Moreover, ALA was administered orally 20 mg/kg once a day by gavage. The outcome data was analyzed using one-way analysis of variance and significance level of (P≤0.05). Findings: The results showed that irisin levels increased significantly in training, supplementation and supplementation+training groups than diabet group (P=0.001). Visfatin (P=0.021), Glucose and insulin-resistance significantly decreased in training and supplementation+ training groups than control group (P=0.011, P=0.008 respectively). Conclusion: It seems that combination of moderate intensity interval training and Alpha lipoic acid can have a positive effect on diabetes control by increasing irisin and decreasing visfatin, glucose and insulin- resistance levels.
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