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  • The Effect of Rosa Damascena Extract on Diazinon Toxicity in Mice

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کد مقاله : JCHR-2110-1422 (R1) بازدید : 220 صفحه: 721 - 728

10.22034/jchr.2021.1941985.1422

نوع مقاله: پژوهشی

The Effect of Rosa Damascena Extract on Diazinon Toxicity in Mice

محورهای موضوعی :

Oveys Pourmahdi 1 , Tohid Moradi Gardeshi 2 , Ali Amirkhani 3 , Majid Gholami-Ahangaran 4

1 - Undergraduate of Veterinary Medicine Faculty, Babol Branch, Islamic Azad University, Babol, Iran
2 - Undergraduate of Veterinary Medicine Faculty, Garmsar Branch, Islamic Azad University, Garmsar, Iran
3 - Undergraduate of Veterinary Medicine Faculty, Babol Branch, Islamic Azad University, Babol, Iran
4 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

تاریخ دریافت : 1400/07/13 تاریخ پذیرش : 1402/02/11 تاریخ انتشار : 1402/09/10

کلید واژه: Toxicity, Mice, Oxidative stress, diazinon, Rosa damascene,

چکیده مقاله :

Diazinon (DNZ) is one of the most widely used organophosphorus poisons, which plays an important role in chemical pest control by controlling a wide range of chewing and sucking pests in gardens and fields. Diazinon causes death in living organisms by reducing cholinesterase and disrupting nerve cells. In this research, the effect of Rosa damascena extract against DNZ toxicity and oxidative damage induced by DZN in mice was studied. The mice toxified with DNZ (32.5 mg kg-1, intraperitoneally) and treated by pralidoxime (PM) (20 mg kg-1, intraperitoneally) or R. Damascena extract (50, 100, 200 mg kg-1, orally) daily for two weeks. In the end, the acetylcholinesterase (AchE), ferric-reducing antioxidant power (FRAP), Malondialdehyde (MDA), ALT, AST, ALP, and total bilirubin were assayed. DZN administration significantly lowered the AchE, and FRAP and increased the MDA (P < 0.05). However, R. Damascena extracts treatment caused a significant reduction in MDA level and restored the levels of AchE and FRAP as well as significantly prevented the DZN-induced increase in liver aminotransferases, ALP, and total bilirubin. We found that R. Damascena administration nearly eliminated DZN-induced toxicity by preventing oxidative stress in mice.

چکیده انگلیسی:

منابع و مأخذ:


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