Potential Harmful Effects of Aflatoxin M1 in Milk and Milk Products and Novel Methods to Reduction of Aflatoxin M1: A Review
محورهای موضوعی :Aliasghar Manouchehri 1 , Mohadeseh Pirhadi 2 , Pouya Parsaei 3 , Hossein Safian Boldaji 4
1 - Assistant Professor, Department of Internal Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol Iran
2 - Department of Environmental Health Engineering, Division of Food Safety & Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3 - Department of Food Hygiene, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran |Research Center of Nutrition and Organic Products (RCNOP), Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
4 - Department of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
کلید واژه: absorption, Contamination, Toxicity, Milk, Restructuring, Aflatoxin M1, Reducing,
چکیده مقاله :
Dairy products are rich sources of vitamins, proteins and calcium that are vital to the human body. Aflatoxin M1 is a hydroxylated metabolite of aflatoxin B1. The presence of this toxin in milk has caused serious concern among nutritionists. Consumption of aflatoxin-contaminated milk (AFM1) may lead to serious health problems in humans. AFM1 causes various cancers such as liver cancer, damage to the nervous and DNA, as well as mutagenicity and teratogenicity. In reducing the amount of aflatoxin in the product, with does not affect the milk quality is of particular importance. Absorption and restructuring methods such as yeast, lactic acid (bacteria), enzymes, ozon, and cold plasma have been used for this purpose. In this study, they have been studied on aflatoxin M1 and toxicology besides reducing method for aflatoxin M1.
1. Milićević D.R., Spirić D., Radičević T., Velebit B., Stefanović S., Milojević L., Janković S., 2017. A review of the current situation of aflatoxin M1 in cow’s milk in Serbia: risk assessment and regulatory aspects. Food Addit Contaminants: Part A, 34, 1617-1631.
2. WHO, 2002. Evaluation of certain mycotoxins in food: fifty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain mycotoxins in food: fifty-sixth report of the Joint FAO/WHO expert committee on food additives. https://apps.who.int/iris/handle/10665/42448
3. Joint F., 2002. Evaluation of certain mycotoxins in food: fifty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives, World Health Organ Tech Rep Ser. 2002;906:i-viii, 1-62.
4. Assi S.H.A., 2019. Determination of Aflatoxin M1 Levels in Milk and Milk-based Products in Gaza Strip, Palestine. Al-Azhar University-Gaza, 1-45.
5. Fallah A.A., Fazlollahi R., Emami A., 2016. Seasonal study of aflatoxin M1 contamination in milk of four dairy species in Yazd, Iran. Food Cont. 68, 77-82.
6. Khaneghahi Abyaneh H., Bahonar A., Noori N., Yazdanpanah H., Shojaee Aliabadi M.H., 2019. Aflatoxin M1 in raw, pasteurized and UHT milk marketed in Iran. Food Addit Contaminants: Part B, 12, 236-244.
7. Ruangwises N., Ruangwises S., 2010. Aflatoxin M1 contamination in raw milk within the central region of Thailand. Bulletin Environ Contamination Toxicol. 85, 195-198.
8. Anttila A., Bhat R V., Bond J.A., Borghoff S J., Bosch F.X., Carlson G.P., Castegnaro M., Cruzan G., Gelderblom W. C., Hass U., 2002. IARC monographs on the evaluation of carcinogenic risks to humans: Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC monographs on the evaluation of carcinogenic risks to humans, 82.
9. Kamkar A., Jahed K G.R., Alavi S., 2011. Occurrence of aflatoxin M1 in raw milk produced in Ardebil of Iran.Iranian J Environm Health Sci Engin. 8(2), 123-128
10. Jaiswal P., Jha S.N., Kaur J., Borah A., Ramya H., 2018. Detection of aflatoxin M1 in milk using spectroscopy and multivariate analyses. Food Chem. 238, 209-214.
11. Bukari N., Kwofie M.K., Adeboye O., 2020. Aflatoxin M1 (Aspergillus parasiticus, flavus) Occurrences in Milk and Milk Products and Its Possible Health Effects. Adv Microbiol. 10, 509.
12. Pardakhti A., Maleki S., 2019. Risk assessment of Aflatoxin M1 contamination of milk in Iran. Int J Environmental Res. 13, 265-271.
13. Li H, Xing L., Zhang M., Wang J., Zheng N., 2018. The toxic effects of aflatoxin B1 and aflatoxin M1 on kidney through regulating L-proline and downstream apoptosis. Bio Med Res Int. 12, 9074861.
14. Duarte S., Almeida A., Teixeira A., Pereira A., Falcão A., Pena A., Lino C., 2013. Aflatoxin M1 in marketed milk in Portugal: Assessment of human and animal exposure. Food Cont. 30, 411-417.
15. Salari N., Kazeminia M., Vaisi-Raygani A., Jalali R., Mohammadi M., 2020. Aflatoxin M1 in Milk Worldwide from 1988 to 2020: A Systematic Review and Meta-Analysis. J Food Quality. Article ID 8862738, 14 pageshttps://doi.org/10.1155/2020/8862738
16. Palizban M., Jahed G., Pakbin B., 2016. Aflatoxin M1 contamination of cow’s raw milk in different seasons from Qazvin province, Iran. J Biol Today's World. 5, 173-176.
17. Akbar N., Nasir M., Naeem N., Ahmad M.U.D., Iqbal S., Rashid A., Imran M., Aslam Gondal T., Atif M., Salehi B., 2019. Occurrence And Seasonal Variations of Aflatoxin M1 In Milk From Punjab, Pakistan. Toxins. 11, 573-574.
18. Panariti E., 2001. Seasonal variations of aflatoxin M1 in the farm milk in Albania. Arhiv za Higijenu Rada Toksiko. 52, 37-41.
19. Yosef T., Al-Julaifi M., Salah-El-Dein W., Al-Rizqi A., 2013. Assessment of aflatoxin M1 residues in raw cow milk at Al-Riyadh area with reference to some detoxification applications. Life Sci J. 10(1), 4365-4369.
20. Fallah A.A., Rahnama M., Jafari T., Saei-Dehkordi S.S., 2011. Seasonal variation of aflatoxin M1 contamination in industrial and traditional Iranian dairy products. Food Cont. 22, 1653-1656.
21. Oruc H., Sonal T., 2001. Determination of aflatoxin M1 levels in cheese and milk consumed in Bursa, Turkey. Vet Human Toxicol. 43, 292-293.
22. Garrido N., Iha M., Santos Ortolani M., Duarte Favaro R., 2003. Occurrence of aflatoxins M1 and M2 in milk commercialized in Ribeirão Preto-SP, Brazil. Food Addit Contaminants. 20, 70-73.
23. Bilandžić N., Varenina I., Kolanović B.S., Božić Đ., Đokić M., Sedak M., Tanković S., Potočnjak D., Cvetnić Ž., 2015. Monitoring of aflatoxin M1 in raw milk during four seasons in Croatia. Food Cont. 54, 331-337.
24. Rahmani J., Alipour S., Miri A., Fakhri Y., Riahi S.M., Keramati H., Moradi M., Amanidaz N., Pouya R.H., Bahmani Z., 2018. The prevalence of aflatoxin M1 in milk of Middle East region: a systematic review, meta-analysis and probabilistic health risk assessment. Food Chem Toxicol. 118, 653-666.
25. Sarvar Taherabadi M., Gharavi M.J., Javadi I., Alimohammadi M., Moghadamnia S.H., Mosleh N.M., Farajollahi M., Sharif M., 2016. The level of Aflatoxin M1 in raw and pasteurized milk produced in Alborz Province, Iran. Jundishapur J Nat Pharmac Prod. 11 (4), 31708.
26. Liu B.H., Chu K.C., Yu F.Y., 2016. Novel monoclonal antibody-based sensitive enzyme-linked immunosorbent assay and rapid immunochromatographic strip for detecting aflatoxin M1 in milk. Food Cont. 66, 1-7.
27. Wang J.J., Liu B.H., Hsu Y.T., Yu F.Y., 2011. Sensitive competitive direct enzyme-linked immunosorbent assay and gold nanoparticle immunochromatographic strip for detecting aflatoxin M1 in milk. Food Cont. 22, 964-969.
28. Lee D., Lee K.G., 2015. Analysis of aflatoxin M1 and M2 in commercial dairy products using high-performance liquid chromatography with a fluorescence detector. Food Cont. 50, 467-471.
29. Iqbal S.Z., Jinap S., Pirouz A., Faizal A.A., 2015. Aflatoxin M1 in milk and dairy products, occurrence and recent challenges: A review. Trends Food Sci Technol. 46, 110-119.
30. Carvalho K., Goncalves G., Lopes A., Santos E., Vargas E., Magalhães W., 2012. Modelling uncertainty estimation for the determination of aflatoxin M1 in milk by visual and densitometric thin-layer chromatography with immunoaffinity column clean-up. Food Addit Contaminants: Part A. 29, 679-693.
31. OSSA D.E.H., Hincapie D.A.,Peñuela G.A., 2015. Determination of aflatoxin M1 in ice cream samples using immunoaffinity columns and ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Food Cont. 56, 34-40.
32. Pour S.H., Mahmoudi S., Masoumi S., Rezaie S., Barac A., Ranjbaran M., Oliya S., Mehravar F., Sasani E., Noorbakhsh F., 2020. Aflatoxin M1 contamination level in Iranian milk and dairy products: A systematic review and meta-analysis. World Mycotoxin J. 13, 67-82.
33. Corassin C., Bovo F., Rosim R., Oliveira C., 2013. Efficiency of Saccharomyces cerevisiae and lactic acid bacteria strains to bind aflatoxin M1 in UHT skim milk. Food Cont. 31, 80-83.
34. Nguyen T., Flint S., Palmer J., 2020. Control of aflatoxin M1 in milk by novel methods: A review. Food Chem. 311, 125984.
35. Assaf J.C., Atoui A., Khoury A.E., Chokr A. Louka N., 2018. A comparative study of procedures for binding of aflatoxin M1 to Lactobacillus rhamnosus GG. Brazilian J Microbiol. 49, 120-127.
36. Abdelmotilib N.M., Hamad G.M., Elderea H.B., Salem E.G., Sohaimy S.A., 2018. Aflatoxin M1 reduction in milk by a novel combination of probiotic bacterial and yeast strains. Eur J Nutr Food Safety. 83-99.
37. Gu X., Sun J., Cui Y., Wang X., Sang Y., 2019. Biological degradation of aflatoxin M1 by Bacillus pumilus E‐1‐1‐1. Microbiol Open. 8, 00663.
38. Sarimehmetoğlu B., Kuplulu Ö., 2004. Binding Ability of Aflatoxin M1 To Yoghurt Bacteria. Ankara Üniv Vet Fak Derg. 51, 195-198.
39. Pierides M., El-Nezami H., Peltonen K., Salminen S., Ahokas J., 2000. Ability of dairy strains of lactic acid bacteria to bind aflatoxin M1 in a food model. J Food Prot. 63, 645-650.
40. Elsanhoty R.M., Salam S.A., Ramadan M.F., Badr F.H., 2014. Detoxification of aflatoxin M1 in yoghurt using probiotics and lactic acid bacteria. Food Contr. 43, 129-134.
41. Kuharić Ž., Jakopović Ž., Čanak, I., Frece, J., Bošnir, J., Pavlek, Ž., Ivešić, M., Markov K., 2018. Removing aflatoxin M1 from milk with native lactic acid bacteria, centrifugation, and filtration. Arhiv za Higijenu Rada Toksiko. 69, 334-339.
42. Shetty P.H., Jespersen L., 2006. Saccharomyces cerevisiae and lactic acid bacteria as potential mycotoxin decontaminating agents. Trends Food Sci Technol. 17, 48-55.
43. Ismail A., Levin R.E., Riaz M., Akhtar S., Gong Y.Y., De Oliveira C.A., 2017. Effect of different microbial concentrations on binding of aflatoxin M1 and stability testing. Food Contr. 73, 492-496.
44. Guan S., Zhao L., Ma Q., Zhou T., Wang N., Hu X., Ji C., 2010. In vitro efficacy of Myxococcus fulvus ANSM068 to biotransform aflatoxin B1. Int J Molec Sci. 11, 4063-4079.
45. Rao K.R., Vipin A., Hariprasad P., Appaiah K.A., Venkateswaran G., 2017. Biological detoxification of Aflatoxin B1 by Bacillus licheniformis CFR1. Food Control. 71, 234-241.
46. Zhao L., Guan S., Gao X., Ma Q., Lei Y., Bai X., Ji C., 2011. Preparation, purification and characteristics of an aflatoxin degradation enzyme from Myxococcus fulvus ANSM068. J Appl Microbiol. 110, 147-155.
47. Motomura M., Toyomasu T., Mizuno K., Shinozawa T., 2003. Purification and characterization of an aflatoxin degradation enzyme fromPleurotus ostreatus. Microbiolog Res. 158, 237-242.
48. Adebo O.A., Njobeh P.B., Mavumengwana V., 2016. Degradation and detoxification of Afb1 by staphylocococcus warneri, sporosarcina Sp. and lysinibacillus fusiformis. Food Contr. 68, 92-96.
49. Akbas M.Y., Ozdemir M., 2006. Effect of different ozone treatments on aflatoxin degradation and physicochemical properties of pistachios. J Sci Food Agri. 86, 2099-2104.
50. Luo X., Wang R., Wang L., Li Y., Bian Y., Chen Z., 2014. Effect of ozone treatment on aflatoxin B1 and safety evaluation of ozonized corn. Food Contr. 37, 171-176.
51. Agriopoulou S., Koliadima A., Karaiskakis G., Kapolos J., 2016. Kinetic study of aflatoxins' degradation in the presence of ozone. Food Contr. 61, 221-226.
52. De Jesus Benevides C.M., Da Cunha Veloso M.C., De Paula Pereira P.A., De Andrade J.B., 2011. A chemical study of β-carotene oxidation by ozone in an organic model system and the identification of the resulting products. Food Chem. 126, 927-934.
53. Diao E., Hou H., Chen B., Shan C., Dong H., 2013. Ozonolysis efficiency and safety evaluation of aflatoxin B1 in peanuts. Food Chem Toxicol. 55, 519-525.
54. De Alencar E.R., Faroni L.R.D.A., Soares N.D.F.F., Da Silva W.A., Da Silva Carvalho M.C., 2012. Efficacy of ozone as a fungicidal and detoxifying agent of aflatoxins in peanuts. J Sci Food Agri. 92, 899-905.
55. Silva R.A., Montes R.H., Richter E.M., Munoz R.A., 2012. Rapid and selective determination of hydrogen peroxide residues in milk by batch injection analysis with amperometric detection. Food Chem. 133, 200-204.
56. Özkan M., Kırca A., Cemerolu B., 2004. Effects of hydrogen peroxide on the stability of ascorbic acid during storage in various fruit juices. Food Chem. 88, 591-597.
57. Diao E., Hou H., Dong H., 2013. Ozonolysis mechanism and influencing factors of aflatoxin B1: A review. Trends Food Sci Technol. 33, 21-26.
58. Diaz G.J.M., 2011. Biotransformation of Aflatoxin B1 and Its Relationship with the Differential Toxicological Response to Aflatoxin in Commercial Poultry Species. In Aflatoxin. Biochem Molecular Biol. 11(3), 4-23.
59. Samuel M.S., Sivaramakrishna A., Mehta A., 2014. Degradation and detoxification of aflatoxin B1 by Pseudomonas putida. Int Biodeterio Biodegrad. 86, 202-209.
60. Kim H.J., Yong H.I., Park S., Kim K., Choe W., Jo C., 2015. Microbial safety and quality attributes of milk following treatment with atmospheric pressure encapsulated dielectric barrier discharge plasma. Food Contr. 47, 451-456.
61. Korachi M., Ozen F., Aslan N., Vannini L., Guerzoni M.E., Gottardi D., Ekinci F.Y., 2015. Biochemical changes to milk following treatment by a novel, cold atmospheric plasma system. Int Dairy J. 42, 64-69.
62. Ragni L., Berardinelli A., Vannini L., Montanari C., Sirri F., Guerzoni M.E., Guarnieri A., 2010. Non-thermal atmospheric gas plasma device for surface decontamination of shell eggs. J Food Engin. 100, 125-132.
63. Pirhadi M., Shariatifar N., Bahmani M., Manouchehri A.A., 2021. Heavy metals in wheat grain and its impact on human health: A review. J Chem Health Risks. 10.22034/jchr.2021.1924307.1269
64. Bahmani M., 2019. A new method for promoting biologic synthesis and reducing the size of titanium dioxide nanoparticles (TiO2 NPs) synthesized by Origanum vulgare. Plant Biotechnol Persa. 1(1), 10-12.
65. Farzan B., Shahsavari S., Abbaszadeh S., Teimouri H., 2019. Phytotherapy for seizure: An overview of the most important indigenous Iranian medicinal plants with anticonvulsant properties. Plant Sci Today. 6(4), 367-372.
66. Manouchehri A., Shakib P., Biglaryan F., Nazer M., Darvishi M., 2021. The most important medicinal plants affecting bee stings: A systematic review study. Uludag Aricilik Dergisi. 21(1), 91-103.
67. Farzan B., Abbaszadeh S., Teimouri H., 2019. Ethnobotanical treatments for earache and sore throat. Int J Res Pharma Sci. 10(2), 1354-1360.
68. Esmaeili A., Parsaei P., Nazer M.R., Bakhtiari R., Mirbehresi H., Safian Boldaji H., 2021. Phytotherapy in Burn Wound Healing: A Review of Native Iranian Medicinal Plants. J Chem Health Risks. 11(0), doi: 10.22034/jchr.2021.1932188.1322
69. Farzan B., Abbaszadeh S., Basati G., Teimouri H., 2019. An overview of the most important medicinal plants effective on the strength of memory and mind in Iranian ethnobotany. J Pharmacy Pharmacog Res.7(3), 156-162.
70. Abbasi N., Khalighi Z., Eftekhari Z., Bahmani M., 2020. Extraction and phytoanalysis of chemical compounds of Eucalyptus globulus leaf native to Dehloran, Ilam province, Iran by HS-SPME and GC-MS. Adv Animal Vet Sci. 8(6), 647-652.
71. Aidy A., Karimi E., Ghaneialvar H., Mohammadpour S., Abbasi N., 2020. Protective effect of Nectaroscordum tripedale extract and its bioactive component tetramethylpyrazine against acetaminophen-induced hepatotoxicity in rats. Adv Trad Med. 20(3), 471-477.
72. Karimi E., Abbasi S.,Abbasi N., 2019. Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: Involvement of growth factors and integrin-linked kinase. Drug Des, Develop Thera. 13, 2513-2532.
73. Abbasi N., Khosravi A., Aidy A., Shafiei M., 2016. Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iran J Med Sci. 41(2), 118-125.
74. Nouri A., Heidarian E, Amini-Khoei H, Abbaszadeh S., Basati G., 2019. Quercetin through mitigation of inflammatory response and oxidative stress exerts protective effects in rat model of diclofenac-induced liver toxicity. J Pharmacy Pharmacog Res. 7(3), 200-212.
