An efficient one-pot synthesis of α-amino nitriles using ecofriendly Lewis-acidic ionic liquid choline chloride.2ZnCl2

محورهای موضوعی : Iranian Journal of Catalysis

Abdol Hajipour ¹ (Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA.)
Ifa Mahboobi Dehbane ² (Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran.)

تاریخ دریافت : 1391/02/25 تاریخ پذیرش : 1391/10/02 تاریخ انتشار : 1391/09/11

کلید واژه: α-Amino nitriles, Strecker reaction, Trimethylsilylcyanide, Choline chloride,

چکیده مقاله :

α-Amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes (or ketones), aniline, and trimethylsilyl cyanide using a catalytic amount of choline chloride.2ZnCl2 as a bio Lewis acidic ionic liquid. Mild Lewis acidic characteristic of this ionic liquid allows efficient synthesis of α-amino nitriles from acid sensitive aldehydes.

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