چاپرون ها، مولکول های حیاتی در میکروب¬ها
محورهای موضوعی : ژنتیک مولکولی میکروارگانیسم ها
کیمیا گلستان فر
1
(دانشجوی دکتری،گروه میکروبیولوژی، دانشکده علوم پایه، واحد شهرکرد، دانشگاه آزاد اسلامي، شهرکرد، ايران)
کلید واژه: چاپرون, فولدینگ, استرس دمایی,
چکیده مقاله :
چاپرون¬های مولکولی پروتئین¬های بسیار حفاظت شده ای هستند که تاخوردگی مناسب سایر پروتئین¬ها را در داخل بدن ترویج می¬کنند. سیستم‌های چاپرون متنوع به فولد کردن و انتقالات پروتئین، جمع‌آوری کمپلکس‌های الیگومری، و بازیابی از باز شدن ناشی از استرس کمک می‌کنند. یک عملکرد اساسی چاپرون¬های مولکولی مهار فعل و انفعالات پروتئین غیرمولد با شناسایی و محافظت از سطوح آبگریز است که در هنگام تا شدن یا به دنبال استرس پروتئوتوکسیک در معرض قرار می¬گیرند. بنابراین چاپرون ها در سیستم¬های سلولی از اهمیت ویژه ای برخوردار هستند که در این مقاله مروری در مورد این مولکول¬ها و مکانیسم¬های عمل آن¬ها، بحث شده است. هم¬چنین در مورد تغییرات بیان ژن در شرایط اکسیداتیو در باکتری در راستای تحمل شرایط محیطی بحث خواهد شد.
Molecular chaperones are highly conserved proteins that promote proper folding of other proteins inside the body. Diverse chaperone systems contribute to protein folding and translocation, assembly of oligomeric complexes, and recovery from stress-induced unfolding. A fundamental function of molecular chaperones is to inhibit nonproductive protein interactions by recognizing and protecting hydrophobic surfaces that are exposed during folding or following proteotoxic stress. Therefore, chaperones are of special importance in cellular systems, which are discussed in this review article about these molecules and their mechanisms of action. Also, changes in gene expression in oxidative conditions in bacteria will be discussed in order to tolerate environmental conditions.
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