Preparation and Characterization of Curcumin-Silver Nanoparticle and Evaluation of the Effect of Poly Ethylene Glycol and Temperature
Parisa Adibzadeh
1
(
Department of Food Sciences & Technology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran (IAUPS).
)
Negar Motakef-Kazemi
2
(
Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
)
Keywords: antibacterial activity, Curcumin, temperature, silver nanoparticle, poly ethylene glycol,
Abstract :
In this research, the silver nanoparticle (AgNP) was rapidly prepared by simple solution method within 1 hour at room temperature and 80 °C in the present and the absent poly ethylene glycol (PEG). The curcumin-silver nanoparticle was synthesized from silver nitrate as precursor and sodium bore hydrate as reduction in two conditions included water solvent and poly ethylene glycol in water solvent at room temperature as solution method and 80 °C as hydrothermal method. The samples were characterized by Fourier transforms infrared spectroscopy (FTIR) for determination of functional groups, x-ray diffraction (XRD) for investigation of crystalline structure, scanning electron microscopy (SEM) for definition of morphology and size, and thermogravimetric analysis (TGA) for measuring of loading. The antibacterial activity of the samples was measured by agar diffusion method against Escherichia coli (E. coli) that affected silver nanoparticle and curcumin. Based on the results, curcumin-AgNP nanoparticle was developed potential for antibacterial application.