Antiplasmodial ativity of akaloids from Garcinia Parvifolia Miq. Stem Bark
Subject Areas : Journal of the Iranian Chemical ResearchU.Z. Lathifah 1 , R.A. Rahima 2 , H. Sudrajat 3 , S. Khairi 4
1 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden
11800, Penang, Malaysia
2 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden
11800, Penang, Malaysia
3 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia
4 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia
Keywords: Isoquinoline alkaloids, Garcinia Parvifolia Miq, Antiplasmodial,
Abstract :
Garciniavalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids,cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), wereisolated and characterized from Garcinia Parvifolia Miq. stem bark. Structural elucidation ofthese compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4)exhibited antiplasmodial activity against Plasmodium falciparum
[1] S. Jones, Morphology and Major Taxonomy of Garcinia (Guttiferae). Ph.D. dissertation, University
of Leicester and British Museum, London, 1980.
[2] P.W. Grasvenol, A. Supriono, D.A. Gray, J. Ethnopharmacol. 45 (1995) 97-111.
[3] K. Likhitwitayawuit, T. Phadungcharoen, J. Krungkrai, Planta Med. 64 (1998) 70-72.
[4] A.E. Hay, J. Helesbeux, O. Duval, M. Lay, P. Grellier, P. Richomne, Life Sci. 75 (2004) 3077-3085.
[5] M. Linuma, H. Tosa, R. Tanaka, F. Shimano, T. Asai, Y. Shigetomo, Phytochemistry. 35 (1994)
1355-1360.
[6] Likhitwitayawuit, W. Chamahasathien, N. Ruangrungsi, J. Krungkrai, Planta Med. 64 (1998) 281-
182.
[7] M.M. Mackeen, A.M. Ali, N.H. Lajis, K. Kawazu, Z. Hassan, M. Amran, M. Habsah, L.Y. Mooi,
S.M. Mohamed, J. Ethnopharmacol. 72 (2000) 395-402.
[8] Mustofa, E.N. Solikhah, S. Wahyuono, J. Trop. Public Health. 38 (2007) 609-615.
[9] R.S. Phillips, Clin. Microbial. Rev. 14 (2001) 155-171.
[10] P.G. Waterman, I. Muhammad, Phytochemistry. 24 (1985) 523-528.
[11] A.J. Marsaioli, A.F. Magalhaes, E.A. Rùveda, F. Reis, Phytochemistry. 19 (1980) 995-1002.
[12] M. Hamonniere, M. Leboeuf, A. Cavé, Phytochemistry. 16 (1977) 1029-1036.
[13] T. Murningsih, Subekti, K. Matsuura, H. Takahashi, M. Yamasaki, O. Yamamoto, Y. Maeda, K.
Katakura, M. Suzuki, S. Kobayashi, T. Chairul, J. Yoshihara, Vet. Med. Sci. 67 (2005) 829-831.