Effect of Suregada zanzibariensis (Baill) root extract on blood sugar levels, lipid profile and pancreatic histology on streptozotocin-nicotinamide induced diabetes mellitus rats
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)Japhet Josephat 1 , Cyprian Beda Mpinda 2 , Rose Masau 3
1 - Molecular Biology and Biotechnology, Natural and Applied Science, University of Dar es salaam;
2 - Molecular Biology and Biotechnology, Natural and Applied Science, University of Dar es salaam;
3 - Molecular Biology and Biotechnology, Natural and Applied Science, University of Dar es salaam;
Keywords: Cholesterol, Streptozotocin, Phytochemical, Lipid profiles, Antidiabetic, β-cells,
Abstract :
Background & Aim: Ethnobotanical studies have shown that Suregada zanzibariensis roots are used by traditional healers and the community for the treatment of diabetes mellitus. Therefore, this study was undertaken to investigate the effect of the ethyl acetate extract ofSuregada zanzibariensis roots (EAESZ) on blood sugar levels, lipid profile, and pancreatic histology in streptozotocin-nicotinamide-induced diabetic rats.Experimental: Rats were induced to have diabetes by interstitial injection of streptozotocin nicotinamide, followed by daily oral administration of the ethyl acetate extract of Suregada zanzibariensis roots (EAESZ) for 28 days at doses of 350, 500, and 700 mg/kg body weight. The effect of EAESZ on serum lipid profiles and pancreatic β-cells in diabetic rats were examined after 28 days of administration of the extract. While fasting, blood glucose levels were measured every seven days.Results: The administration of EAESZ at doses of 350, 500, and 750 mg/kg significantly decreased the fasting blood glucose levels compared to the diabetic control rats. Also, total cholesterol (TC), low-density lipoprotein (LDL), and triglyceride (TG) levels decreased while high-density lipoprotein (HDL) levels increased in all treated groups compared to diabetic control rats. Furthermore, there was no significant difference (P>0.05) in body weight of treated diabetic rats compared to standard control diabetic rats, while there was a significant difference (P<0.05) with diabetic control rats.Recommended applications/industries: These results indicate that EAESZ has high antidiabetic potential along with significant hypoglycemic and hypolipidemic effects. However, more studies are needed to identify and isolate compounds responsible for those properties.
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