Reaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes

Subject Areas :

1 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran
2 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran

Received: 2016-05-25 Accepted : 2016-05-25 Published : 2011-05-01

Keywords: 3-hydroxy pyridine, dialkyl acetylene dicarboxylates, Alkyl isocyanide, multi component reaction, 4H-chromenes,

Abstract :

The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields.

References:

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Reaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes