Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

Subject Areas :

Mohammad Hosein Farjam ¹ , Ramin Rezaei ²

1 - Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran
2 - Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran

Received: 2017-11-01 Accepted : 2018-01-19 Published : 2018-03-01

Keywords:

Abstract :

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.

References:

Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
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Tributyl hexadecyl phosphonium bromide as a new and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidinones/thiones via a three component condensation reactions
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Theoretical study of HCX (NH2) (X= O, S, and Se) analogs in the gas phase: Electronic Structure, Natural Bond Orbital (NBO) & Natural Resonance Theory (NRT)
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Study of the effects of solvent and temperature on the Connections of the MTX and L-FMTX with single-walled carbon nanotubes using QM and MM
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Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds