تاثیر یک دوره تمرین هوازی همراه با مکمل استویا روی هپاتوکاین‌ها و مقاومت به انسولین در موش‌های دیابتی نوع یک
محورهای موضوعی :
فصلنامه زیست شناسی جانوری
اسماعیل پیری
1
(گروه فیزیولوژی ورزشی و حرکات اصلاحی، دانشگده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران)
اکبر نوری حبشی
2
(گروه فیزیولوژی ورزشی و حرکات اصلاحی، دانشگده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران)
محمد رضا ذولفقاری دیدنی
3
(گروه فیزیولوژی ورزشی و حرکات اصلاحی، دانشگده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران)
تاریخ دریافت : 1401/06/23
تاریخ پذیرش : 1401/10/18
تاریخ انتشار : 1402/06/01
کلید واژه:
استویا,
تمرین هوازی,
مقاومت به انسولین,
دیابت نوع 1,
چکیده مقاله :
دیابت یکی از دلایل اصلی مرگ و میر در کشورهای در حال توسعه است. از راه های پیشگیری از دیابت و جلوگیری از عوارض ناشی از آن، انجام فعالیت بدنی و استفاده از مکمل های آنتی اکسیدانی است. هدف از پژوهش حاضر بررسی تاثیر یک دوره تمرین هوازی و مکمل استویا روی فتوئین b، پنتراکسین ۳ و GDF-15 پلاسما و مقاومت به انسولین در موش‌های دیابتی نوع 1 بود. برای این منظور 25 موش دیابتی نوع یک به 5 گروه کنترل-سالم، کنترل دیابت، دیابت مکمل، دیابت تمرین و دیابت تمرین-مکمل تقسیم شدند. برنامه تمرینی رت ها برای مدت 65 روز، با سرعت 20 تا 30 متر بر دقیقه با شدت 10 تا 25 متر/دقیقه بود. دوز مصرفی استویا 250 میلی گرم/کیلوگرم وزن بدن به صورت گاواژ دریافت شد. کشتار موش‌ها 48 ساعت بعد از آخرین جلسه تمرینی انجام و خونگیری انجام شد. جهت مقایسه بین گروه‌ها از آزمون آنالیز واریانس یک طرفه و آزمون تعقیبی بونفرونی استفاده شد. بررسی تغییرات بین گروهی نشان داد که تفاوت معنی دار بین گروه‌ها برای فتوئین b، پنتراکسین ۳ و GDF-15 پلاسما وجود دارد (001/0p <). بررسی تغییرات بین کروهی نشان داد که فتوئین B و GDF-15 افزایش معنی دار و پنتراکسین کاهش معنی دار در گروه سالم نسبت به گروه دیابتی داشتند (001/0p <). همچنین بین گروه کنترل دیابت با گروه های تمرین مکمل و تمرین تفاوت معنی دار بین همه شاخص ها وجود داشت (001/0p <). نتایج پژوهش حاضر نشان داد که تمرین هوازی و مکمل استویا میتوانند باعث کاهش مقاومت به انسولین، فتوئین b و GDF-15 و افزایش پنتراکسین ۳ در موش‌های دیابتی نوع 1 شوند. این بهبودها در گروهی که تمرین و مکمل را به طور همزمان مصرف کرده بودند، بیشتر بود.
چکیده انگلیسی:
Diabetes is one of the main causes of death in developing countries. One of the ways to prevent diabetes and its complications is to do physical activity and use antioxidant supplements. The aim of this study was to investigate the effect of aerobic training and stevia on fetuin b, pentraxin 3 and GDF-15 in plasma and insulin resistance in type 1 diabetic rats. For this purpose, 25 type 1 diabetic mice were divided into 5 groups: healthy control, diabetes control, supplemental diabetes, training diabetes, and training-supplement diabetes. The training program of the rats was for a period of 65 days, with a speed of 20 to 30 m/min and an intensity of 10-25 m/min. Stevia dosage was 250 mg per kilogram of body weight by gavage. Mice were killed 48 hours after the last training session and blood sampling was done. To compare between groups, one-way ANOVA and Bonferroni's post hoc test were used. Examining the changes between groups showed that there is a significant difference between the groups for fetoin b, pentraxin 3 and plasma GDF-15 (p < 0.001). Examining the changes between groups showed that fetoin B and GDF-15 had a significant increase and pentraxin had a significant decrease in the healthy group compared to the diabetic group (p < 0.001). Also, there was a significant difference between the diabetes control group and the supplement and exercise groups in all indicators (p < 0.001. The results of the present study showed that aerobic exercise and stevia supplementation can decrease fetoin b and GDF-15 and increase pentraxin 3 in type 1 diabetic rats. These improvements were better in the group that took exercise and supplementation at the same time.
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