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کد مقاله : ASCIJ-2306-1505 (R1) بازدید : 251 صفحه: 203 - 218

10.22034/ascij.2023.1989804.1505

نوع مقاله: پژوهشی

مروری برکاربرد نانوذرات کیتوسان در درمان انواع سرطان و بررسی سمیت سلولی آنها

محورهای موضوعی : فصلنامه زیست شناسی جانوری

الهام رستمی 1 (گروه شیمی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران)

تاریخ دریافت : 1402/04/04 تاریخ پذیرش : 1402/06/12 تاریخ انتشار : 1402/12/01

کلید واژه: کیتوسان, نانوذرات, سمیت سلولی, انتقال هدفمند دارو,

چکیده مقاله :

کیتوسان یکی از مناسب‌ترین بیوپلیمرها با امکانات گسترده برای بهبود بخشیدن ویژگی‌های جدید نانو دارو و استفاده در زمینه‌های زیست دارویی است که از کیتین دی‌استیل و آمینو‌پلی‌ساکارید ساخته شده است. ویژگی‌های متنوع دارو از جمله خاصیت کاتیونی و رهایش کنترل شده به دلیل وجود گروه عاملی آمینی نوع اول در کیتوسان است. این ویژگی‌های عالی، زیست‌سازگاری، زیست‌تخریب پذیری و ظرفیت بارگذاری، راه‌حل کارآمدی برای جلوگیری از واکنش‌های نامطلوب می‌باشند. با اصلاح نانوذرات کیتوسان که بطور رایج به عنوان حامل دارو تولید و استفاده می‌شوند، سمیت و عوارض جانبی ناشی از تجویزات کاهش داده می‌شوند. دستیابی به رسانش هدفمند دارو، با استفاده از پپتید‌ها، آنتی‌بادی ها، آپتامر یا مولکول‌های کوچک میسر می‌شود. روش‌های ذکر شده دوز میزان استفاده از داروی لازم را کاهش می‌دهند. بعلاوه، آنها دارو را به سمت بافت هدف هدایت می‌کنند. این مقاله مروری با هدف نشان دادن اهمیت ویژگی‌های نانوذرات متصل به آنتی‌بادی، مغناطیسی، کیتوسان مزدوج حساس به pH، در انتقال هدفمند دارو انجام شد. همچنین اثر انواع این نانوذرات بر رده‌های مختلف سلول‌های سرطانی، سمیت سلولی انواع نانوذرات و فارماکوکینتیک آنها مورد بررسی قرار گرفته است. روش گردآوری اطلاعات استفاده از پایگاه های علمی Scopus، Elsevier و PubMed می باشد.

چکیده انگلیسی:

Chitosan, made of deacetylated of chitin and the amino polysaccharide, is one of the greatest convenient biopolymers, which has large possibilities to be modified for new features of nano-medicine and being used in biomedical fields. Having responsibility of various features such as cationic nature and controlled drug release, are to the primary amine functional groups in chitosan. There are great properties, such as biocompatibility, biodegradability, loading capacity and an efficient way to avoid undesirable reactions, since the toxicity and side effects of systemic administration are reduced by adjusting Chitosan NPs, they are commonly synthesized as drug carriers. Achieving targeted delivery of drug is due to using peptides, antibodies, aptamer or small molecules. Mentioned methods lower using dosage of adequate drugs. Additionally, they lead the drugs to the targets. Also, the cytotoxicity studies of various nanoparticles and their pharmacokinetic studies have been carried out. The purpose of this review article is to show the importance of the characteristics of antibody-bound, magnetic, pH-sensitive conjugated chitosan nanoparticles in targeted drug delivery and to investigate the effect of these nanoparticles on different types of cancer cells.

منابع و مأخذ:


  1. Agnihotri S.A., Mallikarjuna, N.N., Aminabhavi T.M. 2004. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. Journal of Control Release, 100(1):5-28.
    2.
  2. Albinali K.E., Zagho M.M., Deng Y., Elzatahry A.A. 2019. A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems. International Journal of Nanomedicine, 14:1707.
    3.
  3. Ali A., Ahmed S. 2018. A review on chitosan and its nanocomposites in drug delivery. International Journal of Biological Macromolecules, 109:273-286.
    4.
  4. Anirudhan T., Nair S.S. 2019. Polyelectrolyte complexes of carboxymethyl chitosan/alginate based drug carrier for targeted and controlled release of dual drug. Journal of Drug Delivery Science and Technology, 51:569-582.
    5.
  5. Archana D., Singh B.K., Dutta J., Dutta P. 2013. In vivo evaluation of chitosan–PVP–titanium dioxide nanocomposite as wound dressing material. Carbohydrate Polymers, 95(1):530-539.
    6.
  6. Bilal M., Zhao Y., Rasheed T., Ahmed I.; Hassan S.T.S., Nawaz M.Z., Iqbal H.M.N. 2019. Magnetic nanoparticles as versatile carriers for enzymes immobilization: A review. International Journal of Environ Res Public Health. 16(4):1-14.
    7.
  7. Calvo P., Remuñan-López C., Vila-Jato J.L., Alonso M.J. 1997. Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines. Pharmaceutical Research, 4(10):1431-1436.
    8.
  8. Chen Y., Qi Y., Liu B. 2013. Polyacrylic acid functionalized nanographene as a nanocarrier for loading and controlled release of doxorubicin hydrochloride. Journal of Nanomaterials, 2013:345738.
    9.
  9. Chu X.Y., Huang W., Wang Y.L., Meng L.W., Chen L.Q., Jin M.J., 2019. Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex. International Journal of Nanomedicine, 14:689.
    10.
  10. Dash M., Chiellini F., Ottenbrite R.M., Chiellini E. 2011. Chitosan—A versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science, 36(8):981-1014.
    11.
  11. Ding Y., Shen S.Z., Sun H., Sun K., Liu F., Qi Y., 2015. Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery. Materials Science and Engineering: C, 48:487-498.
    12.
  12. Drioli E., Giorno L. 2016. Encyclopedia of Membranes, Springer, Berlin, 886–887.
    13.
  13. Dünnhaupt S., Barthelmes J., Rahmat D., Leithner K., Thurner C.C., Friedl H., 2012. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties. Molecular Pharmaceutics, 9(5):1331-1341.
    14.
  14. Ehrlich H. 2010. Chitin and collagen as universal and alternative templates in biomineralization. International Geology Review, 52(7-8):661-699.
    15.
  15. García-Couce J., Bada-Rivero N., López Hernández O.D., Nogueira A., Caracciolo P.C., Abraham G.A., 2019. Dexamethasone-loaded chitosan beads coated with a pH-dependent interpolymer complex for colon-specific drug delivery. International Journal of Polymer Science, 2019:4204375.
    16.
  16. Ghosh A., Ali M.A. 2012. Studies on physicochemical characteristics of chitosan derivatives with dicarboxylic acids. Journal of Materials Science, 47:1196-1204.
    17.
  17. Gupta R, Sharma D. 2019. Evolution of magnetic hyperthermia for glioblastoma multiforme therapy. ACS Chemical Neuroscience, 10(3):1157-1172.
    18.
  18. Havemeyer A., Bittner F., Wollers S, Mendel R., Kunze T., Clement B. 2012. Self-Assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation. Drug Metabolism Reviews, 44(sup1):6-28.
    19.
  19. Hosseinzadeh S., Hosseinzadeh H., Pashaei S., Khodaparast Z. 2019. Synthesis of stimuli-responsive chitosan nanocomposites via RAFT copolymerization for doxorubicin delivery. International Journal of Biological Macromolecules, 121:677-685.
    20.
  20. Hu R., Zheng H., Cao J., Davoudi Z., Wang Q. 2017. Synthesis and in vitro characterization of carboxymethyl chitosan-CBA-doxorubicin conjugate nanoparticles as pH-sensitive drug delivery systems. Journal of Biomedical Nanotechnology, 13(9):1097-1105.
    21.
  21. Huang W.T, Larsson M, Wang Y.J, Chiou S.H, Lin H.Y, Liu D.M. 2015. Demethoxycurcumin-carrying chitosan–antibody core–shell nanoparticles with multitherapeutic efficacy toward malignant A549 lung tumor: From in vitro characterization to in vivo evaluation. Molecular Pharmaceutics, 12(4):1242-1249.
    22.
  22. Kamat , Marathe I., Ghormade V., Bodas D., Paknikar K. 2015. Synthesis of Monodisperse Chitosan Nanoparticles and in Situ Drug Loading Using Active Microreactor. ACS Appl Mater Interfaces, 7(41):22839-22847.
    23.
  23. Kashyap P.L., Xiang X., Heiden P. 2015. Chitosan nanoparticle based delivery systems for sustainable agriculture. International Journal of Biological Macromolecules, 77:36-51.
    24.
  24. Khan S., Anwar N. 2019. Highly porous pH-responsive carboxymethyl chitosan-grafted-poly (acrylic acid) based smart hydrogels for 5-fluorouracil controlled delivery and colon targeting. International Journal of Polymer Science, 2019: 6579239.
    25.
  25. Kim D.H., Nikles D.E., Brazel C.S. 2010. Synthesis and characterization of multifunctional chitosan-MnFe2O4 nanoparticles for magnetic hyperthermia and drug delivery. Materials, 3(7):4051-4065.
    26.
  26. Lim E.K., Huh Y.M., Yang J., Lee K., Suh J.S., Haam S. 2011. pH‐triggered drug‐releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI. Advanced Materials, 23(21):2436-2442.
    27.
  27. Ma Q., Gao Y., Sun W., Cao J., Liang Y., Han S. 2020. Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery. Drug Delivery, 27(1):200-215.
    28.
  28. Mahmoudi K., Bouras A., Bozec D., Ivkov R., Hadjipanayis C. 2018. Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. International Journal of Hyperthermia, 34(8):1316-1328.
    29.
  29. Maya S., Kumar L.G., Sarmento B, Rejinold N.S., Menon D., Nair S.V., Jayakumar R. 2013. Cetuximab conjugated O-carboxymethyl chitosan nanoparticles for targeting EGFR overexpressing cancer cells. Carbohydrate Polymers, 93(2):661-669.
    30.
  30. Mazzotta E., De Benedittis S., Qualtieri A., Muzzalupo R. 2020. Actively targeted and redox responsive delivery of anticancer drug by chitosan nanoparticles. Pharmaceutics, 12(1):26.
    31.
  31. Meler J., Grimling B., Pluta J. 2012. Studies of Norfloxacin adsorption on chitosan. Progress on Chemistry and Application of Chitin and its Derivatives, 17:103-110.
    32.
  32. Mohammadi F., Safari J. 2022. Properties, modification methods and applications of chitosan, Nano chitosan and their derivatives. Journal of applied research in chemisry, 16(1):1-19.
    33.
  33. Monsalve Y., Tosi G., Ruozi B., Belletti D., Vilella A., Zoli M. 2015. PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting. Nanomedicine, 10(11):1735-1750.
    34.
  34. Muller R.H., Keck C.M. 2004. Challenges and solutions for the delivery of biotech drugs–a review of drug nanocrystal technology and lipid nanoparticles. Journal of Biotechnology, 113(1-3):151-170.
    35.
  35. Nagpal K., Singh S.K., Mishra D.N. 2010. Chitosan nanoparticles: a promising system in novel drug delivery. Chemical and Pharmaceutical Bulletin, 58(11):1423-1430.
    36.
  36. Naruphontjirakul P., Viravaidya-Pasuwat K. 2019. Development of anti-HER2-targeted doxorubicin–core-shell chitosan nanoparticles for the treatment of human breast cancer. International Journal of Nanomedicine, 14:4105.
    37.
  37. Park B.G., Kang H.S., Lee W., Kim J.S., Son T.I. 2013. Reinforcement of pH‐responsive γ‐poly (glutamic acid)/chitosan hydrogel for orally administrable colon‐targeted drug delivery. Journal of Applied Polymer Science, 127(1):832-836.
    38.
  38. Rahimi M., Safa K.D., Alizadeh E., Salehi R. 2017. Dendritic chitosan as a magnetic and biocompatible nanocarrier for the simultaneous delivery of doxorubicin and methotrexate to MCF-7 cell line. New Journal of Chemistry, 41(8):3177-3189.
    39.
  39. Rouget C. 1859. Des substances amylacées dans les tissus des animaux, spécialement des Articulés (chitine). Comptes Rendus, 48:792-795.
    40.
  40. Sarmento B., das Neves J. 2012. Targeting and polymer therapeutics. John Wiley and Sons, U.K.
    41.
  41. Sharifi M., Rezayat S.M., Akhtari K., Hasan A., Falahati M. 2020. Fabrication and evaluation of anti-cancer efficacy of lactoferrin-coated maghemite and magnetite nanoparticles. Journal of Biomolecular Structure and Dynamics, 38(10):2945-2954.
    42.
  42. Sheikholeslami Z.S., Salimi-Kenari H., Imani M., Ata M., Nodehi A. 2017. Exploring the effect of formulation parameters on the particle size of carboxymethyl chitosan nanoparticles prepared via reverse micellar crosslinking. Journal of Microencapsulation, 34(3):270-279.
    43.
  43. Sivaramakrishna D., Bhuvanachandra B., Mallakuntla M.K., Das S.N., Ramakrishna B., Podile A.R. 2020. Pretreatment with KOH and KOH-urea enhanced hydrolysis of α-chitin by an endo-chitinase from Enterobacter cloacae subsp. cloacae. Carbohydrate Polymers, 235:115952.
    44.
  44. Subhapradha N., Shanmugam A. 2017. Chitosan nanoparticles from marine squid protect liver cells against N-diethylnitrosoamine-induced hepatocellular carcinoma. International Journal of Biological Macromolecules, 94:194-201.
    45.
  45. Sun X., Liu .C, Omer A., Yang L.Y., Ouyang X.K. 2019. Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil. International Journal of Biological Macromolecules, 132:487-494.
    46.
  46. Tan H, Chu CR, Payne KA, Marra KG. 2009. Injectable in situ forming biodegradable chitosan–hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials, 30(13):2499-2506.
    47.
  47. Tian X., Yin H., Zhang S., Luo Y., Xu K., Ma P. 2014. Bufalin loaded biotinylated chitosan nanoparticles: an efficient drug delivery system for targeted chemotherapy against breast carcinoma. European Journal of Pharmaceutics and Biopharmaceutics, 87(3):445-453.
    48.
  48. Tsai W.H., Yu K.H., Huang Y.C., Lee C.I. 2018. EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles. International Journal of Nanomedicine, 13:903.
    49.
  49. Turon P., Del Valle L.J., Alemán C., Puiggalí J. 2017. Biodegradable and biocompatible systems based on hydroxyapatite nanoparticles. Applied Sciences, 7(1):60.
    50.
  50. Vaghani S.S., Patel M.M., Satish C. 2012. Synthesis and characterization of pH-sensitive hydrogel composed of carboxymethyl chitosan for colon targeted delivery of ornidazole. Carbohydrate Research, 347(1):76-82.
    51.
  51. Wang G., Jin L., Dong Y., Niu L., Liu Y., Ren F. 2014. Multifunctional Fe3O4–CdTe@ SiO 2–carboxymethyl chitosan drug nanocarriers: synergistic effect towards magnetic targeted drug delivery and cell imaging. New Journal of Chemistry, 38(2):700-708.
    52.
  52. Wang T., Hou J., Su C., Zhao L., Shi Y. 2017. Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44. Journal of Nanobiotechnology, 15(1):7.
    53.
  53. Wang Y., Qian J., Yang M., Xu W., Wang J., Hou G. 2019. Doxorubicin/cisplatin co-loaded hyaluronic acid/chitosan-based nanoparticles for in vitro synergistic combination chemotherapy of breast cancer. Carbohydrate Polymers, 225:115206.
    54.
  54. Wang, W.; Xue, C.; Mao, X.; 2020. Chitosan: Structural modification, biological activity and application. International Journal of Biological Macromolecules, 164:4532-4546.
    55.
  55. Xie M., Zhang F., Peng H., Zhang Y., Li Y., Xu Y. 2019. Layer-by-layer modification of magnetic graphene oxide by chitosan and sodium alginate with enhanced dispersibility for targeted drug delivery and photothermal therapy. Colloids and Surfaces B: Biointerfaces, 176:462-470
    56.
  56. Yadavalli T., Ramasamy S., Chandrasekaran G., Michael I., Therese H.A., Chennakesavulu R. 2015. Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery. Journal of Magnetism and Magnetic Materials, 380:315-20.
    57.
  57. Yousefpour P, Atyabi F, Vasheghani-Farahani E, Movahedi A-AM, Dinarvand R. 2011. Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab. International Journal of Nanomedicine, 6:1977.
    58.
  58. Zargar V., Asghari M., Dashti A. 2015. A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications. ChemBioEng Reviews, 2(3):204-226.
    59.
  59. Zavisova V., Koneracka M., Gabelova A., Svitkova B., Ursinyova M., Kubovcikova M. 2019. Effect of magnetic nanoparticles coating on cell proliferation and uptake. Journal of Magnetism and Magnetic Materials, 472:66-73.
    60.
  60. Zhang H., Mardyani S., Chan W.C., Kumacheva E. 2006. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules, 7(5):1568-1572.
    61.
  61. Zhang X., Chen F., Ni J. 2009. A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. Drug Delivery, 16(5):280-288.
    62.
  62. Zhang X., Zhang H., Yin L., Hu R., Qiu T., Yin Y. 2016. A pH-sensitive nanosystem based on carboxymethyl chitosan for tumor-targeted delivery of daunorubicin. Journal of Biomedical Nanotechnology, 12(8):1688-1698.
    63.
  63. Zhang E., Xing R., Liu S., Li K., Qin Y., Yu H. 2019. Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy. International Journal of Biological Macromolecules, 126:662-672.
    64.
  64. Zhao L.M., Shi L.E., Zhang Z.L., Chen J.M., Shi D.D., Yang J. 2011. Preparation and application of chitosan nanoparticles and nanofibers. Brazilian Journal of Chemical Engineering, 28(3):353-362.
    65.
  65. Zhu R., Zhang C.G., Liu Y., Yuan Z.G., Chen W.L., Li J.Z. 2015. CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells. Scientific Reports, 5:17904.
    66.
  66. Zhou W., He Y., Liu F., Liao L., Huang X., Li R., Zou Y., Zhou L., Zou L., Liu  2021. Carboxymethyl chitosan-pullulan edible films enriched with galangal essential oil: Characterization and application in mango preservatin . Carbohydrate   Polymers, 256:117579.
    67.
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