بررسی مقایسه‌ای اثرات عصاره چای سیاه (Camella sinensis) بر رفتار شبه اضطرابی در موش‌های صحرایی نر و ماده

محورهای موضوعی : فصلنامه زیست شناسی جانوری

منوچهر یوسفی ¹ (گروه علوم دامی، دانشکده کشاورزی، مجتمع آموزش عالی سراوان، سراوان، ایران)

تاریخ دریافت : 1401/06/25 تاریخ پذیرش : 1401/08/14 تاریخ انتشار : 1402/03/01

کلید واژه: اضطراب, موش صحرایی, چای سیاه, ماز بعلاوه ای شکل مرتفع,

چکیده مقاله :

اختلال اضطرابی یکی از شایع‌ترین بیماری‌های روانی در جهان است و به یکی از حوزه‌های پژوهشی بسیار مهم در داروسازی تبدیل‌شده‌است. بر اساس یک باور سنتی، چای سیاه (Camella sinensis) به‌عنوان یک دارو که فواید زیادی دارد شناخته‌شده است. اما مصرف بیش‌ازحد آن هم‌ دارای عوارضی می باشد. از مهمترین این موارد می‌توان به تپش قلب و اضطراب اشاره کرد که شدت این عوارض ممکن است بین مردان و زنان متفاوت باشند؛ بنابراین مطالعه حاضر باهدف مقایسه اثرات شبه اضطرابی چای سیاه در موش‌های صحرایی نر و ماده انجام شد. برای انجام آزمایش از 28 سر، موش صحرایی شامل 14 نر و 14 ماده استفاده شد. نرها به دو گروه کنترل و تیمار و ماده‌ها هم به همین شکل تقسیم‌بندی شدند. در زمان آزمایش به گروه‌های تیمار به مدت 24 ساعت دم‌نوش چای سیاه و به گروه کنترل طی این مدت به‌جای دم‌نوش آب آشامیدنی داده شد. سپس رفتار موش‌ها به‌منظور بررسی فعالیت آرام‌بخشی (کاهش فعالیت حرکتی) و اضطراب در ماز بعلاوه ای شکل مرتفع مورد آزمایش قرار گرفت. تمامی داده‌ها با استفاده از آزمون T-test مورد تجزیه‌وتحلیل قرار گرفتند. این مطالعه نشان داد که چای سیاه در موش‌های نر دارای اثرات اضطراب زایی و در ماده دارای اثرات ضداضطرابی می‌باشد. احتمالاً اثرات شبه اضطرابی چای سیاه وابسته به جنس است و ممکن است این اثرات تحت تأثیر هورمون‌های جنسی قرار گیرند.

چکیده انگلیسی:

Anxiety disorder is the most common of all mental illnesses in the world and have become one of interesting research topics in pharmaceuticals. According to a traditional belief, black tea (Camella sinensis (CS)) is known as a medicine that has many benefits. But because of its high consumption, it has side effects that can be mentioned as arrythmia and anxiety which severity of these complications may be different between men and women. Therefore, the present study was conducted with the aim of comparing the anxiety-like effects of CS in male and female rats. 28 rats including 14 males and 14 females were used for the experiment. Males were divided into control and treatment groups and females were divided in the same way. During the experiment, the treatment groups were given black tea for 24 hours, and the control group was given drinking water during this period. Then, the behavior of the rats was tested in order to investigate the motor activity and anxiety in the elevated plus maze. Data were analyzed by T-test and all data were shown as Mean±S.E.M. This study showed that CS has anxiogenic effects in male rats and anxiolytic effects in female rats.

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